Protective effect of artemisia annua L. extract against galactose-induced oxidative stress in mice

Mi Hye Kim; Ji Yeon Seo; Kwang Hyun Liu; Jong Sang Kim

doi:10.1371/journal.pone.0101486

Protective effect of artemisia annua L. extract against galactose-induced oxidative stress in mice

Mi Hye Kim
, Ji Yeon Seo
, Kwang Hyun Liu
, Jong Sang Kim

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Artemisia annua L. (also called qinghao) has been well known as a source of antimalarial drug artemisinins. In addition, the herb was reported to have in vitro antioxidative activity. The present study investigated the protective effect of aqueous ethanol extract of Qinghao (AA extract) against D-galactose-induced oxidative stress in C57BL/6J mice. Feeding AA extractcontaining diet lowered serum levels of malondialdehyde and 8-OH-dG that are biomarkers for lipid peroxidation and DNA damage, respectively. Furthermore, AA extract feeding enhanced the activity of NQO1, a typical antioxidant marker enzyme, in tissues such as kidney, stomach, small intestine, and large intestine. In conclusion, AA extract was found to have antioxidative activity in mouse model.

Original language	English
Article number	e101486
Journal	PLoS ONE
Volume	9
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0101486
State	Published - 2 Jul 2014

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title = "Protective effect of artemisia annua L. extract against galactose-induced oxidative stress in mice",

abstract = "Artemisia annua L. (also called qinghao) has been well known as a source of antimalarial drug artemisinins. In addition, the herb was reported to have in vitro antioxidative activity. The present study investigated the protective effect of aqueous ethanol extract of Qinghao (AA extract) against D-galactose-induced oxidative stress in C57BL/6J mice. Feeding AA extractcontaining diet lowered serum levels of malondialdehyde and 8-OH-dG that are biomarkers for lipid peroxidation and DNA damage, respectively. Furthermore, AA extract feeding enhanced the activity of NQO1, a typical antioxidant marker enzyme, in tissues such as kidney, stomach, small intestine, and large intestine. In conclusion, AA extract was found to have antioxidative activity in mouse model.",

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AU - Kim, Jong Sang

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AB - Artemisia annua L. (also called qinghao) has been well known as a source of antimalarial drug artemisinins. In addition, the herb was reported to have in vitro antioxidative activity. The present study investigated the protective effect of aqueous ethanol extract of Qinghao (AA extract) against D-galactose-induced oxidative stress in C57BL/6J mice. Feeding AA extractcontaining diet lowered serum levels of malondialdehyde and 8-OH-dG that are biomarkers for lipid peroxidation and DNA damage, respectively. Furthermore, AA extract feeding enhanced the activity of NQO1, a typical antioxidant marker enzyme, in tissues such as kidney, stomach, small intestine, and large intestine. In conclusion, AA extract was found to have antioxidative activity in mouse model.

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Protective effect of artemisia annua L. extract against galactose-induced oxidative stress in mice

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