Protective effects of ferulic acid in amyloid precursor protein plus presenilin-1 transgenic mouse model of Alzheimer disease

Ji Jing Yan; Jun Sub Jung; Taek Keun Kim; Md Ashraful Hasan; Chang Won Hong; Ju Suk Nam; Dong Keun Song

doi:10.1248/bpb.b12-00798

Protective effects of ferulic acid in amyloid precursor protein plus presenilin-1 transgenic mouse model of Alzheimer disease

Ji Jing Yan, Jun Sub Jung, Taek Keun Kim, Md Ashraful Hasan, Chang Won Hong, Ju Suk Nam, Dong Keun Song

Department of Medicine

Hallym University

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

We previously reported the protective effects of long-term administration of ferulic acid against the in vivo toxicity of β-amyloid peptide administered intracerebroventricularly in mice. In the present study, we investigated the effects of ferulic acid in transgenic amyloid precursor protein (APP)swe/presenilin 1 (PS1)dE9 (APP/PS1) mouse model of Alzheimer disease (AD). Chronic (for 6 months from the age of 6 to 12 months) oral administration of ferulic acid at a dose of 5.3 mg/kg/day significantly enhanced the performance in novel-object recognition task, and reduced amyloid deposition and interleukin-1 beta (IL-1β) levels in the frontal cortex. These results suggest that ferulic acid at a certain dosage could be useful for prevention and treatment of AD.

Original language	English
Pages (from-to)	140-143
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	36
Issue number	1
DOIs	https://doi.org/10.1248/bpb.b12-00798
State	Published - Jan 2013

Keywords

β-amyloid peptide
Alzheimer disease
Amyloid precursor protein
Ferulic acid
Presenilin 1

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abstract = "We previously reported the protective effects of long-term administration of ferulic acid against the in vivo toxicity of β-amyloid peptide administered intracerebroventricularly in mice. In the present study, we investigated the effects of ferulic acid in transgenic amyloid precursor protein (APP)swe/presenilin 1 (PS1)dE9 (APP/PS1) mouse model of Alzheimer disease (AD). Chronic (for 6 months from the age of 6 to 12 months) oral administration of ferulic acid at a dose of 5.3 mg/kg/day significantly enhanced the performance in novel-object recognition task, and reduced amyloid deposition and interleukin-1 beta (IL-1β) levels in the frontal cortex. These results suggest that ferulic acid at a certain dosage could be useful for prevention and treatment of AD.",

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AU - Hong, Chang Won

AU - Nam, Ju Suk

AU - Song, Dong Keun

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Protective effects of ferulic acid in amyloid precursor protein plus presenilin-1 transgenic mouse model of Alzheimer disease

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Keywords

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