Pulmonary embolism concurrent with lung cancer and central emboli predict mortality in patients with lung cancer and pulmonary embolism

Seung Ick Cha, Kyung Min Shin, Jae Kwang Lim, Seung Soo Yoo, Shin Yup Lee, Jaehee Lee, Chang Ho Kim, Jae Yong Park, Won Kee Lee, Chi Young Jung

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Patients with lung cancer commonly experience pulmonary embolism (PE). The aim of the present study was to examine the clinical features of patients with lung cancer and PE and to investigate prognostic factors in these patients. Methods: This retrospective study divided patients with lung cancer and PE into a group of patients with PE diagnosed concomitantly with lung cancer (concurrent group) and a group with PE detected after lung cancer (sequential group), compared the clinical characteristics of patients in the two groups, and investigated prognostic factors in these patients. Results: The study population consisted of the concurrent group [27 patients (10.1%)] and the sequential group [240 patients (89.9%)]. The concurrent group exhibited higher percentages of stage I cancer at the diagnosis of PE [6 (22.2%) vs. 8 (3.3%), P < 0.001] and right ventricular (RV) dilation on computed tomography (CT) [14 (51.9%) vs. 41 (17.1%), P < 0.001], as well as lower rate of small cell carcinoma [1 (3.7%) vs. 49 (20.4%), P=0.036] than the sequential group. PE concurrent with lung cancer [hazard ratio (HR) =2.64, 95% confidence interval (CI): 1.57-4.43, P < 0.001] and central PE (HR =1.46, 95% CI: 1.02-2.10, P=0.04) were independent predictors of mortality in patients with lung cancer and PE. Conclusions: PE concurrent with lung cancer is characterized by more severe PE and infrequent small cell carcinoma. PE concurrent with lung cancer and central emboli may be independent prognostic factors in patients with lung cancer and PE.

Original languageEnglish
Pages (from-to)262-272
Number of pages11
JournalJournal of Thoracic Disease
Volume10
Issue number1
DOIs
StatePublished - 1 Jan 2018

Keywords

  • Computed tomography (CT)
  • Lung cancer
  • Prognosis
  • Pulmonary embolism (PE)
  • Venous thromboembolism (VTE)

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