Abstract
Pyrene-labeled deoxyuridine (UP) and deoxyadenosine (A P) units, which are substituted at the C-5 and C-8 positions, respectively, are fluorescent unnatural nucleosides. When duplexes are formed, these nucleobases feature strong and stable interstrand stacking interactions between the two pyrene units, which compensate for the loss of hydrogen bonding and induce characteristic pyrene excimer emissions.
Original language | English |
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Pages (from-to) | 1475-1477 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 9 |
DOIs | |
State | Published - 28 Feb 2005 |
Keywords
- Excimer
- Fluorescence
- Interstrand stacking
- Nucleotides