TY - JOUR
T1 - Pyridine-derived Schiff base copper (II), zinc (II), and cadmium (II) complexes
T2 - Synthesis, structural properties, biological evaluation, and docking studies
AU - Nayab, Saira
AU - Faisal, Shah
AU - Khan, Waliullah
AU - Ateeq, Muhammad
AU - Khan, Sher Wali
AU - Kim, Eunhee
AU - Lee, Hyosun
N1 - Publisher Copyright:
© 2023 John Wiley & Sons Ltd.
PY - 2023/8
Y1 - 2023/8
N2 - Herein, Cu (II), Zn (II), and Cd (II) complexes, [DEP(M)X2], encompassing the pyridine-derived Schiff-base ligand DEP, where DEP is (E)-N,N-diethyl-2-([pyridine-2-ylmethylene]amino)ethane-1-amine, are synthesized. X-ray diffraction studies reveal distorted square pyramidal geometries for the Cd (II) and Cu (II) complexes, whereas the geometry of [DEP (Zn)Cl2] can best be described as trigonal bipyramidal. The antibacterial potential of DEP and its [DEP(M)X2] complexes were evaluated against four bacterial strains: Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa; five fungal strains: Candida glabrata, Candida albicans, Microsporum canis, Fusarium solani, and Aspergillus flavus; and Leishmania major protozoan. Complexes exhibited superior bactericidal, fungicidal, and leishmanicidal inhibition potential against all tested microbes compared with the free ligand. The preliminary cytotoxic activity of [DEP(M)X2] complexes on breast and colon carcinoma cells, that is, MCF-7cell line and HCT-116 cell line, respectively, revealed that studied complexes showed high cytotoxicity compared with ligand (DEP). Among the studied complexes, [DEP (Cd)Br2] exhibited an excellent inhibitory profile, as confirmed by the docking study. The molecular docking studies showed a good correlation between the biological activities of synthesized metal complexes and docking studies. We have confidence in the contribution of these complexes toward the design of new metal-derived candidates that can treat infectious diseases.
AB - Herein, Cu (II), Zn (II), and Cd (II) complexes, [DEP(M)X2], encompassing the pyridine-derived Schiff-base ligand DEP, where DEP is (E)-N,N-diethyl-2-([pyridine-2-ylmethylene]amino)ethane-1-amine, are synthesized. X-ray diffraction studies reveal distorted square pyramidal geometries for the Cd (II) and Cu (II) complexes, whereas the geometry of [DEP (Zn)Cl2] can best be described as trigonal bipyramidal. The antibacterial potential of DEP and its [DEP(M)X2] complexes were evaluated against four bacterial strains: Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa; five fungal strains: Candida glabrata, Candida albicans, Microsporum canis, Fusarium solani, and Aspergillus flavus; and Leishmania major protozoan. Complexes exhibited superior bactericidal, fungicidal, and leishmanicidal inhibition potential against all tested microbes compared with the free ligand. The preliminary cytotoxic activity of [DEP(M)X2] complexes on breast and colon carcinoma cells, that is, MCF-7cell line and HCT-116 cell line, respectively, revealed that studied complexes showed high cytotoxicity compared with ligand (DEP). Among the studied complexes, [DEP (Cd)Br2] exhibited an excellent inhibitory profile, as confirmed by the docking study. The molecular docking studies showed a good correlation between the biological activities of synthesized metal complexes and docking studies. We have confidence in the contribution of these complexes toward the design of new metal-derived candidates that can treat infectious diseases.
KW - X-ray structures
KW - antimicrobial properties
KW - molecular docking
KW - transition metal complexes
UR - http://www.scopus.com/inward/record.url?scp=85163335500&partnerID=8YFLogxK
U2 - 10.1002/aoc.7163
DO - 10.1002/aoc.7163
M3 - Article
AN - SCOPUS:85163335500
SN - 0268-2605
VL - 37
JO - Applied Organometallic Chemistry
JF - Applied Organometallic Chemistry
IS - 8
M1 - e7163
ER -