Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells

Nguyen Phuong Thao; Le Duc Dat; Ninh Thi Ngoc; Vu Anh Tu; Tran Thi Hong Hanh; Phan Thi Thanh Huong; Nguyen Xuan Nhiem; Bui Huu Tai; Nguyen Xuan Cuong; Nguyen Hoai Nam; Pham Van Cuong; Seo Young Yang; Sohyun Kim; Doobyeong Chae; Young Sang Koh; Phan Van Kiem; Chau Van Minh; Young Ho Kim

doi:10.1016/j.bmcl.2013.01.032

Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells

Nguyen Phuong Thao
, Le Duc Dat
, Ninh Thi Ngoc
, Vu Anh Tu
, Tran Thi Hong Hanh
, Phan Thi Thanh Huong
, Nguyen Xuan Nhiem
, Bui Huu Tai
, Nguyen Xuan Cuong
, Nguyen Hoai Nam
, Pham Van Cuong
, Seo Young Yang
, Sohyun Kim
, Doobyeong Chae
, Young Sang Koh
, Phan Van Kiem
, Chau Van Minh
, Young Ho Kim

Department of Biology Education

Vietnamese Academy of Science and Technology
Chungnam National University
Jeju National University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Three new pyrrole oligoglycosides, astebatheriosides A-C (1-3), and a new furan oligoglycoside, astebatherioside D (4), were isolated from the starfish Asterina batheri by various chromatographic methods. Their structures were elucidated by spectroscopic and chemical methods. Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC₅₀ values of 36.4, 31.6, and 22.8 μM, respectively.

Original language	English
Pages (from-to)	1823-1827
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2013.01.032
State	Published - 15 Mar 2013

Keywords

Asterina batheri
Furan oligoglycoside
Pro-inflammatory cytokine
Pyrrole oligoglycoside
Starfish

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10.1016/j.bmcl.2013.01.032

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Thao, N. P., Dat, L. D., Ngoc, N. T., Tu, V. A., Hanh, T. T. H., Huong, P. T. T., Nhiem, N. X., Tai, B. H., Cuong, N. X., Nam, N. H., Cuong, P. V., Yang, S. Y., Kim, S., Chae, D., Koh, Y. S., Kiem, P. V., Minh, C. V., & Kim, Y. H. (2013). Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells. Bioorganic and Medicinal Chemistry Letters, 23(6), 1823-1827. https://doi.org/10.1016/j.bmcl.2013.01.032

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title = "Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells",

abstract = "Three new pyrrole oligoglycosides, astebatheriosides A-C (1-3), and a new furan oligoglycoside, astebatherioside D (4), were isolated from the starfish Asterina batheri by various chromatographic methods. Their structures were elucidated by spectroscopic and chemical methods. Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 values of 36.4, 31.6, and 22.8 μM, respectively.",

keywords = "Asterina batheri, Furan oligoglycoside, Pro-inflammatory cytokine, Pyrrole oligoglycoside, Starfish",

author = "Thao, \{Nguyen Phuong\} and Dat, \{Le Duc\} and Ngoc, \{Ninh Thi\} and Tu, \{Vu Anh\} and Hanh, \{Tran Thi Hong\} and Huong, \{Phan Thi Thanh\} and Nhiem, \{Nguyen Xuan\} and Tai, \{Bui Huu\} and Cuong, \{Nguyen Xuan\} and Nam, \{Nguyen Hoai\} and Cuong, \{Pham Van\} and Yang, \{Seo Young\} and Sohyun Kim and Doobyeong Chae and Koh, \{Young Sang\} and Kiem, \{Phan Van\} and Minh, \{Chau Van\} and Kim, \{Young Ho\}",

year = "2013",

month = mar,

day = "15",

doi = "10.1016/j.bmcl.2013.01.032",

language = "English",

volume = "23",

pages = "1823--1827",

journal = "Bioorganic and Medicinal Chemistry Letters",

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Thao, NP, Dat, LD, Ngoc, NT, Tu, VA, Hanh, TTH, Huong, PTT, Nhiem, NX, Tai, BH, Cuong, NX, Nam, NH, Cuong, PV, Yang, SY, Kim, S, Chae, D, Koh, YS, Kiem, PV, Minh, CV & Kim, YH 2013, 'Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells', Bioorganic and Medicinal Chemistry Letters, vol. 23, no. 6, pp. 1823-1827. https://doi.org/10.1016/j.bmcl.2013.01.032

Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells. / Thao, Nguyen Phuong; Dat, Le Duc; Ngoc, Ninh Thi et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 23, No. 6, 15.03.2013, p. 1823-1827.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells

AU - Thao, Nguyen Phuong

AU - Dat, Le Duc

AU - Ngoc, Ninh Thi

AU - Tu, Vu Anh

AU - Hanh, Tran Thi Hong

AU - Huong, Phan Thi Thanh

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Cuong, Nguyen Xuan

AU - Nam, Nguyen Hoai

AU - Cuong, Pham Van

AU - Yang, Seo Young

AU - Kim, Sohyun

AU - Chae, Doobyeong

AU - Koh, Young Sang

AU - Kiem, Phan Van

AU - Minh, Chau Van

AU - Kim, Young Ho

PY - 2013/3/15

Y1 - 2013/3/15

N2 - Three new pyrrole oligoglycosides, astebatheriosides A-C (1-3), and a new furan oligoglycoside, astebatherioside D (4), were isolated from the starfish Asterina batheri by various chromatographic methods. Their structures were elucidated by spectroscopic and chemical methods. Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 values of 36.4, 31.6, and 22.8 μM, respectively.

AB - Three new pyrrole oligoglycosides, astebatheriosides A-C (1-3), and a new furan oligoglycoside, astebatherioside D (4), were isolated from the starfish Asterina batheri by various chromatographic methods. Their structures were elucidated by spectroscopic and chemical methods. Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 values of 36.4, 31.6, and 22.8 μM, respectively.

KW - Asterina batheri

KW - Furan oligoglycoside

KW - Pro-inflammatory cytokine

KW - Pyrrole oligoglycoside

KW - Starfish

UR - https://www.scopus.com/pages/publications/84874645034

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DO - 10.1016/j.bmcl.2013.01.032

M3 - Article

C2 - 23395633

AN - SCOPUS:84874645034

SN - 0960-894X

VL - 23

SP - 1823

EP - 1827

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Thao NP, Dat LD, Ngoc NT, Tu VA, Hanh TTH, Huong PTT et al. Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells. Bioorganic and Medicinal Chemistry Letters. 2013 Mar 15;23(6):1823-1827. doi: 10.1016/j.bmcl.2013.01.032

Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells

Abstract

Keywords

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