Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma

Dong Won Baek; Hee Jeong Cho; Ju Hyung Kim; Sang Kyun Sohn; Ga Young Song; Seo Yeon Ahn; Sung Hoon Jung; Jae Sook Ahn; Je Jung Lee; Hyeoung Joon Kim; Shin Young Jeong; Chae Moon Hong; Jung Joon Min; Joon Ho Moon; Deok Hwan Yang

doi:10.21873/invivo.12018

Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma

Dong Won Baek
, Hee Jeong Cho
, Ju Hyung Kim
, Sang Kyun Sohn
, Ga Young Song
, Seo Yeon Ahn
, Sung Hoon Jung
, Jae Sook Ahn
, Je Jung Lee
, Hyeoung Joon Kim
, Shin Young Jeong
, Chae Moon Hong
, Jung Joon Min
, Joon Ho Moon
, Deok Hwan Yang

Department of Medicine

Kyungpook National University
Chonnam National University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUVbased assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (ΔSUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, ΔSUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.

Original language	English
Pages (from-to)	2127-2134
Number of pages	8
Journal	In Vivo
Volume	34
Issue number	4
DOIs	https://doi.org/10.21873/invivo.12018
State	Published - Aug 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DLBCL
Deauville 5-point scale
Extranodal
Interim PET/CT
SUV

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10.21873/invivo.12018

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Baek, D. W., Cho, H. J., Kim, J. H., Sohn, S. K., Song, G. Y., Ahn, S. Y., Jung, S. H., Ahn, J. S., Lee, J. J., Kim, H. J., Jeong, S. Y., Hong, C. M., Min, J. J., Moon, J. H., & Yang, D. H. (2020). Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma. In Vivo, 34(4), 2127-2134. https://doi.org/10.21873/invivo.12018

@article{fc1d400d8cbf452c91114fe6e0f770a5,

title = "Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma",

abstract = "Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUVbased assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (ΔSUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, ΔSUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.",

keywords = "DLBCL, Deauville 5-point scale, Extranodal, Interim PET/CT, SUV",

author = "Baek, \{Dong Won\} and Cho, \{Hee Jeong\} and Kim, \{Ju Hyung\} and Sohn, \{Sang Kyun\} and Song, \{Ga Young\} and Ahn, \{Seo Yeon\} and Jung, \{Sung Hoon\} and Ahn, \{Jae Sook\} and Lee, \{Je Jung\} and Kim, \{Hyeoung Joon\} and Jeong, \{Shin Young\} and Hong, \{Chae Moon\} and Min, \{Jung Joon\} and Moon, \{Joon Ho\} and Yang, \{Deok Hwan\}",

year = "2020",

month = aug,

doi = "10.21873/invivo.12018",

language = "English",

volume = "34",

pages = "2127--2134",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "4",

}

Baek, DW, Cho, HJ, Kim, JH, Sohn, SK, Song, GY, Ahn, SY, Jung, SH, Ahn, JS, Lee, JJ, Kim, HJ, Jeong, SY, Hong, CM, Min, JJ, Moon, JH & Yang, DH 2020, 'Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma', In Vivo, vol. 34, no. 4, pp. 2127-2134. https://doi.org/10.21873/invivo.12018

TY - JOUR

T1 - Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma

AU - Baek, Dong Won

AU - Cho, Hee Jeong

AU - Kim, Ju Hyung

AU - Sohn, Sang Kyun

AU - Song, Ga Young

AU - Ahn, Seo Yeon

AU - Jung, Sung Hoon

AU - Ahn, Jae Sook

AU - Lee, Je Jung

AU - Kim, Hyeoung Joon

AU - Jeong, Shin Young

AU - Hong, Chae Moon

AU - Min, Jung Joon

AU - Moon, Joon Ho

AU - Yang, Deok Hwan

PY - 2020/8

Y1 - 2020/8

N2 - Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUVbased assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (ΔSUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, ΔSUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.

AB - Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUVbased assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (ΔSUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, ΔSUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.

KW - DLBCL

KW - Deauville 5-point scale

KW - Extranodal

KW - Interim PET/CT

KW - SUV

UR - https://www.scopus.com/pages/publications/85087432408

U2 - 10.21873/invivo.12018

DO - 10.21873/invivo.12018

M3 - Article

C2 - 32606193

AN - SCOPUS:85087432408

SN - 0258-851X

VL - 34

SP - 2127

EP - 2134

JO - In Vivo

JF - In Vivo

IS - 4

ER -

Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma

Abstract

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Keywords

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