Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma

Dong Won Baek; Hee Jeong Cho; Ju Hyung Kim; Sang Kyun Sohn; Ga Young Song; Seo Yeon Ahn; Sung Hoon Jung; Jae Sook Ahn; Je Jung Lee; Hyeoung Joon Kim; Shin Young Jeong; Chae Moon Hong; Jung Joon Min; Joon Ho Moon; Deok Hwan Yang

doi:10.21873/invivo.12018

Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma

Dong Won Baek
, Hee Jeong Cho
, Ju Hyung Kim
, Sang Kyun Sohn
, Ga Young Song
, Seo Yeon Ahn
, Sung Hoon Jung
, Jae Sook Ahn
, Je Jung Lee
, Hyeoung Joon Kim
, Shin Young Jeong
, Chae Moon Hong
, Jung Joon Min
, Joon Ho Moon
, Deok Hwan Yang

Department of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUVbased assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (ΔSUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, ΔSUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.

Original language	English
Pages (from-to)	2127-2134
Number of pages	8
Journal	In Vivo
Volume	34
Issue number	4
DOIs	https://doi.org/10.21873/invivo.12018
State	Published - Aug 2020

Keywords

DLBCL
Deauville 5-point scale
Extranodal
Interim PET/CT
SUV

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.21873/invivo.12018

Cite this

Baek, D. W., Cho, H. J., Kim, J. H., Sohn, S. K., Song, G. Y., Ahn, S. Y., Jung, S. H., Ahn, J. S., Lee, J. J., Kim, H. J., Jeong, S. Y., Hong, C. M., Min, J. J., Moon, J. H., & Yang, D. H. (2020). Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma. In Vivo, 34(4), 2127-2134. https://doi.org/10.21873/invivo.12018

@article{fc1d400d8cbf452c91114fe6e0f770a5,

title = "Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma",

abstract = "Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUVbased assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (ΔSUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, ΔSUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.",

keywords = "DLBCL, Deauville 5-point scale, Extranodal, Interim PET/CT, SUV",

author = "Baek, \{Dong Won\} and Cho, \{Hee Jeong\} and Kim, \{Ju Hyung\} and Sohn, \{Sang Kyun\} and Song, \{Ga Young\} and Ahn, \{Seo Yeon\} and Jung, \{Sung Hoon\} and Ahn, \{Jae Sook\} and Lee, \{Je Jung\} and Kim, \{Hyeoung Joon\} and Jeong, \{Shin Young\} and Hong, \{Chae Moon\} and Min, \{Jung Joon\} and Moon, \{Joon Ho\} and Yang, \{Deok Hwan\}",

year = "2020",

month = aug,

doi = "10.21873/invivo.12018",

language = "English",

volume = "34",

pages = "2127--2134",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "4",

}

Baek, DW, Cho, HJ, Kim, JH, Sohn, SK, Song, GY, Ahn, SY, Jung, SH, Ahn, JS, Lee, JJ, Kim, HJ, Jeong, SY, Hong, CM, Min, JJ, Moon, JH & Yang, DH 2020, 'Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma', In Vivo, vol. 34, no. 4, pp. 2127-2134. https://doi.org/10.21873/invivo.12018

TY - JOUR

T1 - Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma

AU - Baek, Dong Won

AU - Cho, Hee Jeong

AU - Kim, Ju Hyung

AU - Sohn, Sang Kyun

AU - Song, Ga Young

AU - Ahn, Seo Yeon

AU - Jung, Sung Hoon

AU - Ahn, Jae Sook

AU - Lee, Je Jung

AU - Kim, Hyeoung Joon

AU - Jeong, Shin Young

AU - Hong, Chae Moon

AU - Min, Jung Joon

AU - Moon, Joon Ho

AU - Yang, Deok Hwan

PY - 2020/8

Y1 - 2020/8

N2 - Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUVbased assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (ΔSUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, ΔSUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.

AB - Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUVbased assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (ΔSUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, ΔSUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.

KW - DLBCL

KW - Deauville 5-point scale

KW - Extranodal

KW - Interim PET/CT

KW - SUV

UR - https://www.scopus.com/pages/publications/85087432408

U2 - 10.21873/invivo.12018

DO - 10.21873/invivo.12018

M3 - Article

C2 - 32606193

AN - SCOPUS:85087432408

SN - 0258-851X

VL - 34

SP - 2127

EP - 2134

JO - In Vivo

JF - In Vivo

IS - 4

ER -

Quantitative assessment of interim PET/CT could have more prognostic relevance than visual assessment for predicting clinical outcome of extranodal diffuse large B cell lymphoma

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this