Radiosynthesis and in vivo evaluation of [125I]2-(4-iodophenethyl)-2-methylmalonic acid as a potential radiotracer for detection of apoptosis

Jongho Jeon; Ha Eun Shim; Sajid Mushtaq; Jung Ae Kang; You Ree Nam; Seonhye Yoon; Hye Rim Kim; Dae Seong Choi; Beom Su Jang; Sang Hyun Park

doi:10.1007/s10967-015-4346-4

Radiosynthesis and in vivo evaluation of [¹²⁵I]2-(4-iodophenethyl)-2-methylmalonic acid as a potential radiotracer for detection of apoptosis

Jongho Jeon, Ha Eun Shim, Sajid Mushtaq, Jung Ae Kang, You Ree Nam, Seonhye Yoon, Hye Rim Kim, Dae Seong Choi, Beom Su Jang, Sang Hyun Park

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The aim of this study is to synthesize ¹²⁵I-labeled 2-(4-iodophenethyl)-2-methylmalonic acid ([¹²⁵I]IMA) for the development of new apoptosis imaging tracer. The optimized radiolabeling procedure provided [¹²⁵I]IMA with high radiochemical yield (75.5 ± 5.2 %) and radiochemical purity (>99 %) within 100 min. Specific radioactivity of [¹²⁵I]IMA was 31.0 MBq/μmol. Biodistribution study of [¹²⁵I]IMA was carried out using ICR mouse and the result showed the uptake values in apoptotic cells of the testes of the male mice were 1.7–3.2 fold higher than those of leg muscle. Therefore, [¹²⁵I]IMA will be a promising radiotracer for in vivo SPECT imaging of apoptotic cells.

Original language	English
Pages (from-to)	23-29
Number of pages	7
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	308
Issue number	1
DOIs	https://doi.org/10.1007/s10967-015-4346-4
State	Published - 1 Apr 2016

Keywords

I
Apoptosis
Biodistribution
Radiotracer
SPECT/CT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10967-015-4346-4

Cite this

Jeon, J., Shim, H. E., Mushtaq, S., Kang, J. A., Nam, Y. R., Yoon, S., Kim, H. R., Choi, D. S., Jang, B. S., & Park, S. H. (2016). Radiosynthesis and in vivo evaluation of [¹²⁵I]2-(4-iodophenethyl)-2-methylmalonic acid as a potential radiotracer for detection of apoptosis. Journal of Radioanalytical and Nuclear Chemistry, 308(1), 23-29. https://doi.org/10.1007/s10967-015-4346-4

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title = "Radiosynthesis and in vivo evaluation of [125I]2-(4-iodophenethyl)-2-methylmalonic acid as a potential radiotracer for detection of apoptosis",

abstract = "The aim of this study is to synthesize 125I-labeled 2-(4-iodophenethyl)-2-methylmalonic acid ([125I]IMA) for the development of new apoptosis imaging tracer. The optimized radiolabeling procedure provided [125I]IMA with high radiochemical yield (75.5 ± 5.2 %) and radiochemical purity (>99 %) within 100 min. Specific radioactivity of [125I]IMA was 31.0 MBq/μmol. Biodistribution study of [125I]IMA was carried out using ICR mouse and the result showed the uptake values in apoptotic cells of the testes of the male mice were 1.7–3.2 fold higher than those of leg muscle. Therefore, [125I]IMA will be a promising radiotracer for in vivo SPECT imaging of apoptotic cells.",

keywords = "I, Apoptosis, Biodistribution, Radiotracer, SPECT/CT",

author = "Jongho Jeon and Shim, {Ha Eun} and Sajid Mushtaq and Kang, {Jung Ae} and Nam, {You Ree} and Seonhye Yoon and Kim, {Hye Rim} and Choi, {Dae Seong} and Jang, {Beom Su} and Park, {Sang Hyun}",

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doi = "10.1007/s10967-015-4346-4",

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AU - Jeon, Jongho

AU - Shim, Ha Eun

AU - Mushtaq, Sajid

AU - Kang, Jung Ae

AU - Nam, You Ree

AU - Yoon, Seonhye

AU - Kim, Hye Rim

AU - Choi, Dae Seong

AU - Jang, Beom Su

AU - Park, Sang Hyun

PY - 2016/4/1

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AB - The aim of this study is to synthesize 125I-labeled 2-(4-iodophenethyl)-2-methylmalonic acid ([125I]IMA) for the development of new apoptosis imaging tracer. The optimized radiolabeling procedure provided [125I]IMA with high radiochemical yield (75.5 ± 5.2 %) and radiochemical purity (>99 %) within 100 min. Specific radioactivity of [125I]IMA was 31.0 MBq/μmol. Biodistribution study of [125I]IMA was carried out using ICR mouse and the result showed the uptake values in apoptotic cells of the testes of the male mice were 1.7–3.2 fold higher than those of leg muscle. Therefore, [125I]IMA will be a promising radiotracer for in vivo SPECT imaging of apoptotic cells.

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