Recent advances in gadolinium based contrast agents for bioimaging applications

Atiya Fatima; Md Wasi Ahmad; Abdullah Khamis Ali Al Saidi; Arup Choudhury; Yongmin Chang; Gang Ho Lee

doi:10.3390/nano11092449

Recent advances in gadolinium based contrast agents for bioimaging applications

Atiya Fatima, Md Wasi Ahmad, Abdullah Khamis Ali Al Saidi, Arup Choudhury, Yongmin Chang, Gang Ho Lee

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly.

Original language	English
Article number	2449
Journal	Nanomaterials
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/nano11092449
State	Published - Sep 2021

Keywords

Bio-imaging applications
Coating ligands
Gadolinium based contrast agents
Gadolinium oxide nanoparticles
Magnetic resonance imaging
Nanoparticles

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10.3390/nano11092449

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title = "Recent advances in gadolinium based contrast agents for bioimaging applications",

abstract = "Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly.",

keywords = "Bio-imaging applications, Coating ligands, Gadolinium based contrast agents, Gadolinium oxide nanoparticles, Magnetic resonance imaging, Nanoparticles",

author = "Atiya Fatima and Ahmad, {Md Wasi} and {Al Saidi}, {Abdullah Khamis Ali} and Arup Choudhury and Yongmin Chang and Lee, {Gang Ho}",

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AU - Fatima, Atiya

AU - Ahmad, Md Wasi

AU - Al Saidi, Abdullah Khamis Ali

AU - Choudhury, Arup

AU - Chang, Yongmin

AU - Lee, Gang Ho

PY - 2021/9

Y1 - 2021/9

N2 - Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly.

AB - Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly.

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KW - Coating ligands

KW - Gadolinium based contrast agents

KW - Gadolinium oxide nanoparticles

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U2 - 10.3390/nano11092449

DO - 10.3390/nano11092449

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JF - Nanomaterials

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Recent advances in gadolinium based contrast agents for bioimaging applications

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