Recent insights into insulin-like growth factor binding protein 2 transcriptional regulation

Minsang Shin, Hye Suk Kang, Jae Hyung Park, Jae Hoon Bae, Dae Kyu Song, Seung Soon Im

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalEndocrinology and Metabolism
Volume32
Issue number1
DOIs
StatePublished - 1 Mar 2017

Keywords

  • Insulin-like growth factor binding protein 2
  • Liver
  • Metabolic diseases
  • Transcriptional regulation

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