TY - JOUR
T1 - Recent progress in therapeutic drug delivery systems for treatment of traumatic CNS injuries
AU - Khadka, Bikram
AU - Lee, Jae Young
AU - Kim, Ki Taek
AU - Bae, Jong Sup
N1 - Publisher Copyright:
© 2020 Future Medicine Ltd.. All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Most therapeutics for the treatment of traumatic central nervous system injuries, such as traumatic brain injury and spinal cord injury, encounter various obstacles in reaching the target tissue and exerting pharmacological effects, including physiological barriers like the blood-brain barrier and blood-spinal cord barrier, instability rapid elimination from the injured tissue or cerebrospinal fluid and off-target toxicity. For central nervous system delivery, nano- and microdrug delivery systems are regarded as the most suitable and promising carriers. In this review, the pathophysiology and biomarkers of traumatic central nervous system injuries (traumatic brain injury and spinal cord injury) are introduced. Furthermore, various drug delivery systems, novel combinatorial therapies and advanced therapies for the treatment of traumatic brain injury and spinal cord injury are emphasized.
AB - Most therapeutics for the treatment of traumatic central nervous system injuries, such as traumatic brain injury and spinal cord injury, encounter various obstacles in reaching the target tissue and exerting pharmacological effects, including physiological barriers like the blood-brain barrier and blood-spinal cord barrier, instability rapid elimination from the injured tissue or cerebrospinal fluid and off-target toxicity. For central nervous system delivery, nano- and microdrug delivery systems are regarded as the most suitable and promising carriers. In this review, the pathophysiology and biomarkers of traumatic central nervous system injuries (traumatic brain injury and spinal cord injury) are introduced. Furthermore, various drug delivery systems, novel combinatorial therapies and advanced therapies for the treatment of traumatic brain injury and spinal cord injury are emphasized.
KW - combinatorial therapies
KW - drug delivery systems
KW - local and systemic administration
KW - neuronal regeneration
KW - primary and secondary injuries
KW - spinal cord injury
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85094931266&partnerID=8YFLogxK
U2 - 10.4155/fmc-2020-0178
DO - 10.4155/fmc-2020-0178
M3 - Review article
C2 - 33028091
AN - SCOPUS:85094931266
SN - 1756-8919
VL - 12
SP - 1759
EP - 1778
JO - Future Medicinal Chemistry
JF - Future Medicinal Chemistry
IS - 19
ER -