Recovery Effect of a Rutin-Enriched Fraction Prepared From Forsythia koreana Flowers on Alloxan-Induced Pancreatic Islets in Zebrafish Larvae (Danio rerio)

Yeong Geun Lee; Youn Hee Nam; Jung Eun Gwag; Jung Hwan Ko; Kyeong Hwa Seo; Dae Young Lee; Se Chan Kang; Tong Ho Kang; Nam In Baek

doi:10.1177/1934578X211043731

Recovery Effect of a Rutin-Enriched Fraction Prepared From Forsythia koreana Flowers on Alloxan-Induced Pancreatic Islets in Zebrafish Larvae (Danio rerio)

Yeong Geun Lee, Youn Hee Nam, Jung Eun Gwag, Jung Hwan Ko, Kyeong Hwa Seo, Dae Young Lee, Se Chan Kang, Tong Ho Kang, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A simple method to prepare a high-content rutin fraction from Forsythia koreana flowers (HRFK) is described. Rutin, isolated for the first time from the flowers, was identified from spectroscopic data including nuclear magnetic resonance, mass spectrometry, and infrared. As a result of HPLC quantitative analysis, the content of rutin was found to be 80.0 ± 0.02% in HRFK. Our previous study reported that F koreana MeOH extract (FK) significantly recovered alloxan-induced pancreatic islets in zebrafish. However, HRFK as well as rutin exhibited an enhanced anti-diabetic effect compared to FK in our latest experiments. In conclusion, HRFK, as well as rutin and FK, have potential as anti-diabetic agents.

Original language	English
Journal	Natural Product Communications
Volume	16
Issue number	10
DOIs	https://doi.org/10.1177/1934578X211043731
State	Published - 2021

Keywords

diabetes
Forsythia koreana
rutin
zebrafish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578X211043731

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title = "Recovery Effect of a Rutin-Enriched Fraction Prepared From Forsythia koreana Flowers on Alloxan-Induced Pancreatic Islets in Zebrafish Larvae (Danio rerio)",

abstract = "A simple method to prepare a high-content rutin fraction from Forsythia koreana flowers (HRFK) is described. Rutin, isolated for the first time from the flowers, was identified from spectroscopic data including nuclear magnetic resonance, mass spectrometry, and infrared. As a result of HPLC quantitative analysis, the content of rutin was found to be 80.0 ± 0.02% in HRFK. Our previous study reported that F koreana MeOH extract (FK) significantly recovered alloxan-induced pancreatic islets in zebrafish. However, HRFK as well as rutin exhibited an enhanced anti-diabetic effect compared to FK in our latest experiments. In conclusion, HRFK, as well as rutin and FK, have potential as anti-diabetic agents.",

keywords = "diabetes, Forsythia koreana, rutin, zebrafish",

author = "Lee, {Yeong Geun} and Nam, {Youn Hee} and Gwag, {Jung Eun} and Ko, {Jung Hwan} and Seo, {Kyeong Hwa} and Lee, {Dae Young} and Kang, {Se Chan} and Kang, {Tong Ho} and Baek, {Nam In}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021.",

year = "2021",

doi = "10.1177/1934578X211043731",

language = "English",

volume = "16",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

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TY - JOUR

T1 - Recovery Effect of a Rutin-Enriched Fraction Prepared From Forsythia koreana Flowers on Alloxan-Induced Pancreatic Islets in Zebrafish Larvae (Danio rerio)

AU - Lee, Yeong Geun

AU - Nam, Youn Hee

AU - Gwag, Jung Eun

AU - Ko, Jung Hwan

AU - Seo, Kyeong Hwa

AU - Lee, Dae Young

AU - Kang, Se Chan

AU - Kang, Tong Ho

AU - Baek, Nam In

PY - 2021

Y1 - 2021

N2 - A simple method to prepare a high-content rutin fraction from Forsythia koreana flowers (HRFK) is described. Rutin, isolated for the first time from the flowers, was identified from spectroscopic data including nuclear magnetic resonance, mass spectrometry, and infrared. As a result of HPLC quantitative analysis, the content of rutin was found to be 80.0 ± 0.02% in HRFK. Our previous study reported that F koreana MeOH extract (FK) significantly recovered alloxan-induced pancreatic islets in zebrafish. However, HRFK as well as rutin exhibited an enhanced anti-diabetic effect compared to FK in our latest experiments. In conclusion, HRFK, as well as rutin and FK, have potential as anti-diabetic agents.

AB - A simple method to prepare a high-content rutin fraction from Forsythia koreana flowers (HRFK) is described. Rutin, isolated for the first time from the flowers, was identified from spectroscopic data including nuclear magnetic resonance, mass spectrometry, and infrared. As a result of HPLC quantitative analysis, the content of rutin was found to be 80.0 ± 0.02% in HRFK. Our previous study reported that F koreana MeOH extract (FK) significantly recovered alloxan-induced pancreatic islets in zebrafish. However, HRFK as well as rutin exhibited an enhanced anti-diabetic effect compared to FK in our latest experiments. In conclusion, HRFK, as well as rutin and FK, have potential as anti-diabetic agents.

KW - diabetes

KW - Forsythia koreana

KW - rutin

KW - zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85116468892&partnerID=8YFLogxK

U2 - 10.1177/1934578X211043731

DO - 10.1177/1934578X211043731

M3 - Article

AN - SCOPUS:85116468892

SN - 1934-578X

VL - 16

JO - Natural Product Communications

JF - Natural Product Communications

IS - 10

ER -

Recovery Effect of a Rutin-Enriched Fraction Prepared From Forsythia koreana Flowers on Alloxan-Induced Pancreatic Islets in Zebrafish Larvae (Danio rerio)

Abstract

Keywords

UN SDGs

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