Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

Kyeong Hwa Seo; Youn Hee Nam; Dae Young Lee; Eun Mi Ahn; Tong Ho Kang; Nam In Baek

doi:10.1016/j.carres.2015.07.010

Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

Kyeong Hwa Seo, Youn Hee Nam, Dae Young Lee, Eun Mi Ahn, Tong Ho Kang, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.

Original language	English
Pages (from-to)	70-74
Number of pages	5
Journal	Carbohydrate Research
Volume	416
DOIs	https://doi.org/10.1016/j.carres.2015.07.010
State	Published - 30 Oct 2015

Keywords

Alloxan
Anti-diabetic
Magnolia obovata
Obovatoside
Pancreatic islet
Zebrafish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.carres.2015.07.010

Cite this

@article{80a53872300d4f14a824239b56eb23b4,

title = "Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)",

abstract = "Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.",

keywords = "Alloxan, Anti-diabetic, Magnolia obovata, Obovatoside, Pancreatic islet, Zebrafish",

author = "Seo, {Kyeong Hwa} and Nam, {Youn Hee} and Lee, {Dae Young} and Ahn, {Eun Mi} and Kang, {Tong Ho} and Baek, {Nam In}",

year = "2015",

month = oct,

day = "30",

doi = "10.1016/j.carres.2015.07.010",

language = "English",

volume = "416",

pages = "70--74",

journal = "Carbohydrate Research",

issn = "0008-6215",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

AU - Seo, Kyeong Hwa

AU - Nam, Youn Hee

AU - Lee, Dae Young

AU - Ahn, Eun Mi

AU - Kang, Tong Ho

AU - Baek, Nam In

PY - 2015/10/30

Y1 - 2015/10/30

N2 - Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.

AB - Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.

KW - Alloxan

KW - Anti-diabetic

KW - Magnolia obovata

KW - Obovatoside

KW - Pancreatic islet

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=84941555883&partnerID=8YFLogxK

U2 - 10.1016/j.carres.2015.07.010

DO - 10.1016/j.carres.2015.07.010

M3 - Article

C2 - 26364259

AN - SCOPUS:84941555883

SN - 0008-6215

VL - 416

SP - 70

EP - 74

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this