Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

Kyeong Hwa Seo; Youn Hee Nam; Dae Young Lee; Eun Mi Ahn; Tong Ho Kang; Nam In Baek

doi:10.1016/j.carres.2015.07.010

Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

Kyeong Hwa Seo
, Youn Hee Nam
, Dae Young Lee
, Eun Mi Ahn
, Tong Ho Kang
, Nam In Baek

School of Life Science and Biotechnology

Kyung Hee University
Daegu Haany University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.

Original language	English
Pages (from-to)	70-74
Number of pages	5
Journal	Carbohydrate Research
Volume	416
DOIs	https://doi.org/10.1016/j.carres.2015.07.010
State	Published - 30 Oct 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alloxan
Anti-diabetic
Magnolia obovata
Obovatoside
Pancreatic islet
Zebrafish

Access to Document

10.1016/j.carres.2015.07.010

Cite this

@article{80a53872300d4f14a824239b56eb23b4,

title = "Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)",

abstract = "Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.",

keywords = "Alloxan, Anti-diabetic, Magnolia obovata, Obovatoside, Pancreatic islet, Zebrafish",

author = "Seo, \{Kyeong Hwa\} and Nam, \{Youn Hee\} and Lee, \{Dae Young\} and Ahn, \{Eun Mi\} and Kang, \{Tong Ho\} and Baek, \{Nam In\}",

year = "2015",

month = oct,

day = "30",

doi = "10.1016/j.carres.2015.07.010",

language = "English",

volume = "416",

pages = "70--74",

journal = "Carbohydrate Research",

issn = "0008-6215",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

AU - Seo, Kyeong Hwa

AU - Nam, Youn Hee

AU - Lee, Dae Young

AU - Ahn, Eun Mi

AU - Kang, Tong Ho

AU - Baek, Nam In

PY - 2015/10/30

Y1 - 2015/10/30

N2 - Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.

AB - Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A-C (1-3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1-5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish.

KW - Alloxan

KW - Anti-diabetic

KW - Magnolia obovata

KW - Obovatoside

KW - Pancreatic islet

KW - Zebrafish

UR - https://www.scopus.com/pages/publications/84941555883

U2 - 10.1016/j.carres.2015.07.010

DO - 10.1016/j.carres.2015.07.010

M3 - Article

C2 - 26364259

AN - SCOPUS:84941555883

SN - 0008-6215

VL - 416

SP - 70

EP - 74

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this