Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation

Seon Gyeong Bak; Hyung Jin Lim; Yeong Seon Won; Soyoung Lee; Sun Hee Cheong; Seong Jin Lee; Eun Young Bae; Seung Woong Lee; Seung Jae Lee; Mun Chual Rho

doi:10.1155/2022/2475699

Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation

Seon Gyeong Bak
, Hyung Jin Lim
, Yeong Seon Won
, Soyoung Lee
, Sun Hee Cheong
, Seong Jin Lee
, Eun Young Bae
, Seung Woong Lee
, Seung Jae Lee
, Mun Chual Rho

Department of Innovative Pharmaceutical Sciences

Korea Research Institute of Bioscience and Biotechnology
Chonnam National University
Cha Meditech Co. Ltd.
Elohim Co. Ltd

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.

Original language	English
Article number	2475699
Journal	BioMed Research International
Volume	2022
DOIs	https://doi.org/10.1155/2022/2475699
State	Published - 2022

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title = "Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation",

abstract = "Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.",

author = "Bak, \{Seon Gyeong\} and Lim, \{Hyung Jin\} and Won, \{Yeong Seon\} and Soyoung Lee and Cheong, \{Sun Hee\} and Lee, \{Seong Jin\} and Bae, \{Eun Young\} and Lee, \{Seung Woong\} and Lee, \{Seung Jae\} and Rho, \{Mun Chual\}",

note = "Publisher Copyright: {\textcopyright} 2022 Seon Gyeong Bak et al.",

year = "2022",

doi = "10.1155/2022/2475699",

language = "English",

volume = "2022",

journal = "BioMed Research International",

issn = "2314-6133",

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T1 - Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation

AU - Bak, Seon Gyeong

AU - Lim, Hyung Jin

AU - Won, Yeong Seon

AU - Lee, Soyoung

AU - Cheong, Sun Hee

AU - Lee, Seong Jin

AU - Bae, Eun Young

AU - Lee, Seung Woong

AU - Lee, Seung Jae

AU - Rho, Mun Chual

PY - 2022

Y1 - 2022

N2 - Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.

AB - Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.

UR - https://www.scopus.com/pages/publications/85138614815

U2 - 10.1155/2022/2475699

DO - 10.1155/2022/2475699

M3 - Article

C2 - 36158872

AN - SCOPUS:85138614815

SN - 2314-6133

VL - 2022

JO - BioMed Research International

JF - BioMed Research International

M1 - 2475699

ER -

Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation

Abstract

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