TY - JOUR
T1 - Relationship between Human Papillomavirus Status and the Cervicovaginal Microbiome in Cervical Cancer
AU - Nguyen, Hong Duc Thi
AU - Le, Tan Minh
AU - Lee, Eunmi
AU - Lee, Donghyeon
AU - Choi, Yeseul
AU - Cho, Junghwan
AU - Park, Nora Jee Young
AU - Chong, Gun Oh
AU - Seo, Incheol
AU - Han, Hyung Soo
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/6
Y1 - 2023/6
N2 - Uterine cervical cancer (CC) is a complex, multistep disease primarily linked to persistent infection with high-risk human papillomavirus (HR-HPV). However, it is widely acknowledged that HR-HPV infection alone cannot account for the formation and progression of CC. Emerging evidence suggests that the cervicovaginal microbiome (CVM) also plays a significant role in HPV-related CC. Certain bacteria, such as Fusobacterium spp., Porphyromonas, Prevotella, and Campylobacter, are currently being considered as potential microbiomarkers for HPV-positive CC. However, the composition of the CVM in CC is inconsistent; thus, further studies are needed. This review comprehensively discusses the complex interplay between HPV and the CVM in cervical carcinogenesis. It is postulated that the dynamic interaction between HPV and the CVM creates an imbalanced cervicovaginal microenvironment that triggers dysbiosis, enhances HPV persistence, and promotes cervical carcinogenesis. Moreover, this review aims to provide updated evidence on the potential role of bacteriotherapy, particularly probiotics, in the treatment of CC.
AB - Uterine cervical cancer (CC) is a complex, multistep disease primarily linked to persistent infection with high-risk human papillomavirus (HR-HPV). However, it is widely acknowledged that HR-HPV infection alone cannot account for the formation and progression of CC. Emerging evidence suggests that the cervicovaginal microbiome (CVM) also plays a significant role in HPV-related CC. Certain bacteria, such as Fusobacterium spp., Porphyromonas, Prevotella, and Campylobacter, are currently being considered as potential microbiomarkers for HPV-positive CC. However, the composition of the CVM in CC is inconsistent; thus, further studies are needed. This review comprehensively discusses the complex interplay between HPV and the CVM in cervical carcinogenesis. It is postulated that the dynamic interaction between HPV and the CVM creates an imbalanced cervicovaginal microenvironment that triggers dysbiosis, enhances HPV persistence, and promotes cervical carcinogenesis. Moreover, this review aims to provide updated evidence on the potential role of bacteriotherapy, particularly probiotics, in the treatment of CC.
KW - bacteriotherapy
KW - cervical cancer
KW - cervical intraepithelial lesion
KW - cervicovaginal microbiome
KW - human papillomavirus
UR - http://www.scopus.com/inward/record.url?scp=85164106924&partnerID=8YFLogxK
U2 - 10.3390/microorganisms11061417
DO - 10.3390/microorganisms11061417
M3 - Review article
AN - SCOPUS:85164106924
SN - 2076-2607
VL - 11
JO - Microorganisms
JF - Microorganisms
IS - 6
M1 - 1417
ER -
