Restriction of nutrient intake results in the increase of a specific Manduca sexta allatotropin (Manse-AT) mRNA in the larval nerve cord

Kyeong Yeoll Lee; Frank M. Horodyski

doi:10.1016/S0196-9781(01)00659-3

Restriction of nutrient intake results in the increase of a specific Manduca sexta allatotropin (Manse-AT) mRNA in the larval nerve cord

Kyeong Yeoll Lee, Frank M. Horodyski

Ohio University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The Manduca allatotropin (Manse-AT) gene is expressed as three mRNAs that differ from each other by alternative splicing. The level of one of these mRNAs (RNA-3) is specifically increased in the nerve cord of last instar larvae that were starved, parasitized, or fed the ecdysteroid agonist RH-5992. Each of these treatments results in reduction of feeding and increased levels of juvenile hormone (JH). The normal decline in JH biosynthesis by the corpora allata does not occur in starved or RH-5992-fed larvae. The increase in RNA-3 levels has the capacity to increase the production of Manse-AT and two related peptides that may be part of the complex response of larvae to nutrient deprivation.

Original language	English
Pages (from-to)	653-661
Number of pages	9
Journal	Peptides
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/S0196-9781(01)00659-3
State	Published - 2002

Keywords

Alternative splicing
Juvenile hormone
Neuropeptides
Parasitism
Starvation
Tebufenozide

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10.1016/S0196-9781(01)00659-3

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title = "Restriction of nutrient intake results in the increase of a specific Manduca sexta allatotropin (Manse-AT) mRNA in the larval nerve cord",

abstract = "The Manduca allatotropin (Manse-AT) gene is expressed as three mRNAs that differ from each other by alternative splicing. The level of one of these mRNAs (RNA-3) is specifically increased in the nerve cord of last instar larvae that were starved, parasitized, or fed the ecdysteroid agonist RH-5992. Each of these treatments results in reduction of feeding and increased levels of juvenile hormone (JH). The normal decline in JH biosynthesis by the corpora allata does not occur in starved or RH-5992-fed larvae. The increase in RNA-3 levels has the capacity to increase the production of Manse-AT and two related peptides that may be part of the complex response of larvae to nutrient deprivation.",

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AB - The Manduca allatotropin (Manse-AT) gene is expressed as three mRNAs that differ from each other by alternative splicing. The level of one of these mRNAs (RNA-3) is specifically increased in the nerve cord of last instar larvae that were starved, parasitized, or fed the ecdysteroid agonist RH-5992. Each of these treatments results in reduction of feeding and increased levels of juvenile hormone (JH). The normal decline in JH biosynthesis by the corpora allata does not occur in starved or RH-5992-fed larvae. The increase in RNA-3 levels has the capacity to increase the production of Manse-AT and two related peptides that may be part of the complex response of larvae to nutrient deprivation.

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KW - Neuropeptides

KW - Parasitism

KW - Starvation

KW - Tebufenozide

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Restriction of nutrient intake results in the increase of a specific Manduca sexta allatotropin (Manse-AT) mRNA in the larval nerve cord

Abstract

Keywords

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