TY - JOUR
T1 - Revisiting lipids in retinal diseases
T2 - A focused review on age-related macular degeneration and diabetic retinopathy
AU - Park, Su Jin
AU - Park, Dong Ho
N1 - Publisher Copyright:
© 2020 The Korean Society of Lipid and Atherosclerosis.
PY - 2020
Y1 - 2020
N2 - Dyslipidemia refers to an abnormal amount of lipid in the blood, and the total cholesterol level is defined as the sum of high-density lipoprotein cholesterol, low-density lipoprotein (LDL) cholesterol, and very-LDL cholesterol concentrations. In Korea, the westernization of lifestyle habits in recent years has caused an increase in the incidence of dyslipidemia, which is an important risk factor of cardiovascular disease (CVD). Several studies have been conducted on how dyslipidemia affects not only CVD, but also chorioretinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy. Recently, a pathological model of AMD was proposed under the assumption that AMD proceeds through a mechanism similar to that of atherosclerotic CVD. However, controversy remains regarding the relationship between chorioretinal diseases and lipid levels in the blood, and the effects of lipid-lowering agents. Herein, we summarize the role of lipids in chorioretinal diseases. In addition, the effects of lipid-lowering agents on the prevention and progression of chorioretinal diseases are presented.
AB - Dyslipidemia refers to an abnormal amount of lipid in the blood, and the total cholesterol level is defined as the sum of high-density lipoprotein cholesterol, low-density lipoprotein (LDL) cholesterol, and very-LDL cholesterol concentrations. In Korea, the westernization of lifestyle habits in recent years has caused an increase in the incidence of dyslipidemia, which is an important risk factor of cardiovascular disease (CVD). Several studies have been conducted on how dyslipidemia affects not only CVD, but also chorioretinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy. Recently, a pathological model of AMD was proposed under the assumption that AMD proceeds through a mechanism similar to that of atherosclerotic CVD. However, controversy remains regarding the relationship between chorioretinal diseases and lipid levels in the blood, and the effects of lipid-lowering agents. Herein, we summarize the role of lipids in chorioretinal diseases. In addition, the effects of lipid-lowering agents on the prevention and progression of chorioretinal diseases are presented.
KW - Age-related macular degeneration
KW - Cholesterol
KW - Diabetic retinopathy
KW - Hypolipidemic agents
KW - Lipids
UR - http://www.scopus.com/inward/record.url?scp=85098071319&partnerID=8YFLogxK
U2 - 10.12997/jla.2020.9.3.406
DO - 10.12997/jla.2020.9.3.406
M3 - Article
AN - SCOPUS:85098071319
SN - 2287-2892
VL - 9
SP - 406
EP - 418
JO - Journal of Lipid and Atherosclerosis
JF - Journal of Lipid and Atherosclerosis
IS - 3
ER -
