Rhombenone: Farnesyl protein transferase inhibitor from the leaves of Hedera rhombea Bean

Byoung Mog Kwon, Seung Ho Lee, Kyung Sook Kim, Ihn Rhan Lee, Un Chul Lee, Su Hyung Hong, Song Hae Bok

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Rhombenone, a new dammarane analogue containing an 25-oxo, which inhibits farnesyl protein transferase (FPTase), was isolated from the leaves of Hedera rhombea Bean. Additional related dammaranes were also evaluated for FPTase inhibition.

Original languageEnglish
Pages (from-to)971-974
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number8
DOIs
StatePublished - 22 Apr 1997

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