Rhombenone: Farnesyl protein transferase inhibitor from the leaves of Hedera rhombea Bean

Byoung Mog Kwon; Seung Ho Lee; Kyung Sook Kim; Ihn Rhan Lee; Un Chul Lee; Su Hyung Hong; Song Hae Bok

doi:10.1016/S0960-894X(97)00139-X

Rhombenone: Farnesyl protein transferase inhibitor from the leaves of Hedera rhombea Bean

Byoung Mog Kwon
, Seung Ho Lee
, Kyung Sook Kim
, Ihn Rhan Lee
, Un Chul Lee
, Su Hyung Hong
, Song Hae Bok

Department of Dentistry

Korea Institute of Science and Technology
Ewha Womans University
Korea Ginseng/Tobacco Research Inst.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Rhombenone, a new dammarane analogue containing an 25-oxo, which inhibits farnesyl protein transferase (FPTase), was isolated from the leaves of Hedera rhombea Bean. Additional related dammaranes were also evaluated for FPTase inhibition.

Original language	English
Pages (from-to)	971-974
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(97)00139-X
State	Published - 22 Apr 1997

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title = "Rhombenone: Farnesyl protein transferase inhibitor from the leaves of Hedera rhombea Bean",

abstract = "Rhombenone, a new dammarane analogue containing an 25-oxo, which inhibits farnesyl protein transferase (FPTase), was isolated from the leaves of Hedera rhombea Bean. Additional related dammaranes were also evaluated for FPTase inhibition.",

author = "Kwon, \{Byoung Mog\} and Lee, \{Seung Ho\} and Kim, \{Kyung Sook\} and Lee, \{Ihn Rhan\} and Lee, \{Un Chul\} and Hong, \{Su Hyung\} and Bok, \{Song Hae\}",

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T2 - Farnesyl protein transferase inhibitor from the leaves of Hedera rhombea Bean

AU - Kwon, Byoung Mog

AU - Lee, Seung Ho

AU - Kim, Kyung Sook

AU - Lee, Ihn Rhan

AU - Lee, Un Chul

AU - Hong, Su Hyung

AU - Bok, Song Hae

PY - 1997/4/22

Y1 - 1997/4/22

N2 - Rhombenone, a new dammarane analogue containing an 25-oxo, which inhibits farnesyl protein transferase (FPTase), was isolated from the leaves of Hedera rhombea Bean. Additional related dammaranes were also evaluated for FPTase inhibition.

AB - Rhombenone, a new dammarane analogue containing an 25-oxo, which inhibits farnesyl protein transferase (FPTase), was isolated from the leaves of Hedera rhombea Bean. Additional related dammaranes were also evaluated for FPTase inhibition.

UR - https://www.scopus.com/pages/publications/0030950485

U2 - 10.1016/S0960-894X(97)00139-X

DO - 10.1016/S0960-894X(97)00139-X

M3 - Article

AN - SCOPUS:0030950485

SN - 0960-894X

VL - 7

SP - 971

EP - 974

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Rhombenone: Farnesyl protein transferase inhibitor from the leaves of Hedera rhombea Bean

Abstract

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