RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection

Yee Soo Chae, Jong Gwang Kim, Sang Kyun Sohn, Su Jeong Lee, Byung Woog Kang, Joon Ho Moon, Jae Yong Park, Seong Woo Jeon, Han Ik Bae, Gyu Seog Choi, Soo Han Jun

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Since apoptosis plays a key role in cancer progression, the present study analyzed the polymorphisms of apoptosis-related genes and their impact on survival after curative resection in patients with colorectal cancer. Materials and methods: Three hundred and seventy-seven patients were enrolled in the present study. The genomic DNA was extracted from fresh colorectal mucosal tissue, and 15 SNPs of 12 apoptosis-related genes were determined using a Sequenom MassARRAY system. Results: During the median follow-up of 41.8 (range, 1.1-85.5) months patients alive at last follow-up, 65 relapses and 57 deaths occurred. Among the target polymorphisms, the RIPK1 rs2272990 in a dominant model and the CASP7 rs2227310 in a recessive model of the minor allele were associated with survival in a log-rank test. Moreover, the GA+AA genotype of the RIPK1 rs2272990 and the GG genotype of the CASP7 rs2227310 were significantly correlated with a worse disease-free (hazard ratio [HR] = 2.093; P = 0.007 and HR = 2.641; 0.002, respectively) and disease-specific survival (HR = 2.222; P = 0.013 and HR = 2.247; P = 0.031, respectively) in a multivariate survival analysis. Conclusion: The RIPK1 and CASP7 polymorphisms can be considered as possible prognostic markers for survival after curative resection in patients with colorectal cancer.

Original languageEnglish
Pages (from-to)705-713
Number of pages9
JournalJournal of Cancer Research and Clinical Oncology
Volume137
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Apoptosis-related gene
  • Colorectal cancer
  • Polymorphism
  • Prognosis

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