TY - JOUR
T1 - Risk factors of postoperative acute lung injury following lobectomy for nonsmall cell lung cancer
AU - Kim, Hyun Jung
AU - Cha, Seung Ick
AU - Kim, Chang Ho
AU - Lee, Jaehee
AU - Cho, Joon Yong
AU - Lee, Youngok
AU - Kim, Gun Jik
AU - Lee, Deok Heon
N1 - Publisher Copyright:
Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Acute lung injury following lung resection surgery is not rare and often related to mortality. Although it has been a significant clinical and economic impact associated with increased intensive care unit (ICU) utilization, length of hospital stay, and associated cost, it is unpredictable. Aims of this study were to identify the modifiable risk factors of postoperative acute lung injury (PALI) following lung cancer surgery. We retrospectively analyzed medical records of 354 cases of lung cancer surgery in the tertiary university hospital from January 2012 to December 2015. PALI was defined as bilateral diffuse pulmonary infiltration on chest radiography, oxygenation failure (PaO2/FiO2<300), and absence of sign of left ventricular failure within a week from operation. We classified patients into either PALI group or non-PALI group and compared clinical characteristics of two groups. Logistic regression model was fitted to evaluate the risk factor of PALI. Among 354 cases of lung cancer surgeries, 287 lobectomies were analyzed. The overall incidence of PALI was 2.79% (8/287); four patients developed pneumonia with acute respiratory distress syndrome, and four patients developed ALI without clinical infection sign. There was no difference in baseline characteristics between PALI group and non-PALI group, but in operative parameters, a larger amount of fluid infusion was observed in PALI group. Logistic regression model showed underlying ischemic heart disease (OR 7.67, 95% CI 1.21-47.44, P=.03), interstitial lung disease (OR 30.36, 95% CI 2.30-401.52, P=.01), intravascular crystalloid fluid during surgery (OR 1.10, 95% CI 1.00-1.20, P=.04), and intraoperative transfusion (OR 56.4, 95% CI 3.53-901.39, P<.01) were risk factors of PALI. PALI increases ICU admission, use of mechanical ventilator, duration of hospital stay, and mortality. The clinical impact of PALI is marked. Significant independent risk factors have been identified in underlying ischemic heart disease, interstitial lung disease, intravascular crystalloid fluid, and transfusion during surgery.
AB - Acute lung injury following lung resection surgery is not rare and often related to mortality. Although it has been a significant clinical and economic impact associated with increased intensive care unit (ICU) utilization, length of hospital stay, and associated cost, it is unpredictable. Aims of this study were to identify the modifiable risk factors of postoperative acute lung injury (PALI) following lung cancer surgery. We retrospectively analyzed medical records of 354 cases of lung cancer surgery in the tertiary university hospital from January 2012 to December 2015. PALI was defined as bilateral diffuse pulmonary infiltration on chest radiography, oxygenation failure (PaO2/FiO2<300), and absence of sign of left ventricular failure within a week from operation. We classified patients into either PALI group or non-PALI group and compared clinical characteristics of two groups. Logistic regression model was fitted to evaluate the risk factor of PALI. Among 354 cases of lung cancer surgeries, 287 lobectomies were analyzed. The overall incidence of PALI was 2.79% (8/287); four patients developed pneumonia with acute respiratory distress syndrome, and four patients developed ALI without clinical infection sign. There was no difference in baseline characteristics between PALI group and non-PALI group, but in operative parameters, a larger amount of fluid infusion was observed in PALI group. Logistic regression model showed underlying ischemic heart disease (OR 7.67, 95% CI 1.21-47.44, P=.03), interstitial lung disease (OR 30.36, 95% CI 2.30-401.52, P=.01), intravascular crystalloid fluid during surgery (OR 1.10, 95% CI 1.00-1.20, P=.04), and intraoperative transfusion (OR 56.4, 95% CI 3.53-901.39, P<.01) were risk factors of PALI. PALI increases ICU admission, use of mechanical ventilator, duration of hospital stay, and mortality. The clinical impact of PALI is marked. Significant independent risk factors have been identified in underlying ischemic heart disease, interstitial lung disease, intravascular crystalloid fluid, and transfusion during surgery.
KW - acute lung injury
KW - lung neoplasms
KW - nonsmall cell lung cancer
KW - postoperative pulmonary complication
KW - pulmonary surgical procedures
UR - http://www.scopus.com/inward/record.url?scp=85064124359&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000015078
DO - 10.1097/MD.0000000000015078
M3 - Article
C2 - 30921242
AN - SCOPUS:85064124359
SN - 0025-7974
VL - 98
JO - Medicine (United States)
JF - Medicine (United States)
IS - 13
M1 - e15078
ER -