Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury

Sangmin Jeon; Mithilesh Kumar Jha; Jiyeon Ock; Jungwan Seo; Myungwon Jin; Heejung Cho; Won Ha Lee; Kyoungho Suk

doi:10.1074/jbc.M113.454140

Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury

Sangmin Jeon
, Mithilesh Kumar Jha
, Jiyeon Ock
, Jungwan Seo
, Myungwon Jin
, Heejung Cho
, Won Ha Lee
, Kyoungho Suk

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Background: In the central nervous system, the role of LCN2 as a chemokine inducer has been previously reported. Results: Peripheral nerve injury increased LCN2 expression. Lcn2 deficiency attenuated pain hypersensitivity, microglial activation, and chemokine production. Chemokine expression and pain behavior were induced by LCN2. Conclusion: The LCN2-chemokine axis plays a critical role in the pathogenesis of neuropathic pain. Significance: LCN2 can be targeted for treatment of neuropathic pain.

Original language	English
Pages (from-to)	24116-24127
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	33
DOIs	https://doi.org/10.1074/jbc.M113.454140
State	Published - 16 Aug 2013

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title = "Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury",

abstract = "Background: In the central nervous system, the role of LCN2 as a chemokine inducer has been previously reported. Results: Peripheral nerve injury increased LCN2 expression. Lcn2 deficiency attenuated pain hypersensitivity, microglial activation, and chemokine production. Chemokine expression and pain behavior were induced by LCN2. Conclusion: The LCN2-chemokine axis plays a critical role in the pathogenesis of neuropathic pain. Significance: LCN2 can be targeted for treatment of neuropathic pain.",

author = "Sangmin Jeon and Jha, \{Mithilesh Kumar\} and Jiyeon Ock and Jungwan Seo and Myungwon Jin and Heejung Cho and Lee, \{Won Ha\} and Kyoungho Suk",

year = "2013",

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doi = "10.1074/jbc.M113.454140",

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T1 - Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury

AU - Jeon, Sangmin

AU - Jha, Mithilesh Kumar

AU - Ock, Jiyeon

AU - Seo, Jungwan

AU - Jin, Myungwon

AU - Cho, Heejung

AU - Lee, Won Ha

AU - Suk, Kyoungho

PY - 2013/8/16

Y1 - 2013/8/16

N2 - Background: In the central nervous system, the role of LCN2 as a chemokine inducer has been previously reported. Results: Peripheral nerve injury increased LCN2 expression. Lcn2 deficiency attenuated pain hypersensitivity, microglial activation, and chemokine production. Chemokine expression and pain behavior were induced by LCN2. Conclusion: The LCN2-chemokine axis plays a critical role in the pathogenesis of neuropathic pain. Significance: LCN2 can be targeted for treatment of neuropathic pain.

AB - Background: In the central nervous system, the role of LCN2 as a chemokine inducer has been previously reported. Results: Peripheral nerve injury increased LCN2 expression. Lcn2 deficiency attenuated pain hypersensitivity, microglial activation, and chemokine production. Chemokine expression and pain behavior were induced by LCN2. Conclusion: The LCN2-chemokine axis plays a critical role in the pathogenesis of neuropathic pain. Significance: LCN2 can be targeted for treatment of neuropathic pain.

UR - https://www.scopus.com/pages/publications/84882412414

U2 - 10.1074/jbc.M113.454140

DO - 10.1074/jbc.M113.454140

M3 - Article

C2 - 23836894

AN - SCOPUS:84882412414

SN - 0021-9258

VL - 288

SP - 24116

EP - 24127

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 33

ER -

Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury

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