Abstract
Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains of neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). In these diseases, oxidative stress can disrupt the blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, and pathogens to enter the brain, leading to increased ROS production, mitochondrial dysfunction, and inflammation. Collectively, these factors result in protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. In this review article, we present the mechanisms by which oxidative damage leads to BBB breakdown in brain diseases. Additionally, we summarize potential therapeutic approaches aimed at reducing oxidative damage that contributes to BBB disruption in neurodegenerative diseases.
| Original language | English |
|---|---|
| Article number | 1462 |
| Journal | Antioxidants |
| Volume | 13 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2024 |
Keywords
- blood-derived protein
- blood–brain barrier
- neurodegenerative diseases
- oxidative damage
- reactive oxygen species
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