Role of peroxisome proliferator-activated receptor (ppar)δ in embryonic stem cell proliferation

Min Young Lee; Yu Jin Lee; Yun Hee Kim; Sang Hun Lee; Jae Hong Park; Mi Ok Kim; Han Na Suh; Jung Min Ryu; Seung Pil Yun; Min Woo Jang; Ho Jae Han

doi:10.15283/ijsc.2009.2.1.28

Role of peroxisome proliferator-activated receptor (ppar)δ in embryonic stem cell proliferation

Min Young Lee, Yu Jin Lee, Yun Hee Kim, Sang Hun Lee, Jae Hong Park, Mi Ok Kim, Han Na Suh, Jung Min Ryu, Seung Pil Yun, Min Woo Jang, Ho Jae Han

Chonnam National University

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear receptor family. It is well known that PPARs function as regulators of lipid and lipoprotein metabolism and glucose homeostasis, as well as influence cellular proliferation, differentiation and apoptosis. However, the role of the PPARs with regard to embryonic stem (ES) cells remains unknown. We will review the function of the PPARδ, one of the three PPAR isoforms, α, δ (also called β/δ), and γ, in ES cells and its role in embryo development. In addition, pluripotent mouse ES cells can be expanded in large numbers in vitro due to the process of symmetrical self-renewal. Here we describe how PPARδ sustains ES cell proliferation.

Original language	English
Pages (from-to)	28-34
Number of pages	7
Journal	International Journal of Stem Cells
Volume	2
Issue number	1
DOIs	https://doi.org/10.15283/ijsc.2009.2.1.28
State	Published - May 2009

Keywords

ES cells
High glucose
PPARδ
Proliferation

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10.15283/ijsc.2009.2.1.28

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title = "Role of peroxisome proliferator-activated receptor (ppar)δ in embryonic stem cell proliferation",

abstract = "The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear receptor family. It is well known that PPARs function as regulators of lipid and lipoprotein metabolism and glucose homeostasis, as well as influence cellular proliferation, differentiation and apoptosis. However, the role of the PPARs with regard to embryonic stem (ES) cells remains unknown. We will review the function of the PPARδ, one of the three PPAR isoforms, α, δ (also called β/δ), and γ, in ES cells and its role in embryo development. In addition, pluripotent mouse ES cells can be expanded in large numbers in vitro due to the process of symmetrical self-renewal. Here we describe how PPARδ sustains ES cell proliferation.",

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year = "2009",

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AU - Kim, Yun Hee

AU - Lee, Sang Hun

AU - Park, Jae Hong

AU - Kim, Mi Ok

AU - Suh, Han Na

AU - Ryu, Jung Min

AU - Yun, Seung Pil

AU - Jang, Min Woo

AU - Han, Ho Jae

PY - 2009/5

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N2 - The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear receptor family. It is well known that PPARs function as regulators of lipid and lipoprotein metabolism and glucose homeostasis, as well as influence cellular proliferation, differentiation and apoptosis. However, the role of the PPARs with regard to embryonic stem (ES) cells remains unknown. We will review the function of the PPARδ, one of the three PPAR isoforms, α, δ (also called β/δ), and γ, in ES cells and its role in embryo development. In addition, pluripotent mouse ES cells can be expanded in large numbers in vitro due to the process of symmetrical self-renewal. Here we describe how PPARδ sustains ES cell proliferation.

AB - The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear receptor family. It is well known that PPARs function as regulators of lipid and lipoprotein metabolism and glucose homeostasis, as well as influence cellular proliferation, differentiation and apoptosis. However, the role of the PPARs with regard to embryonic stem (ES) cells remains unknown. We will review the function of the PPARδ, one of the three PPAR isoforms, α, δ (also called β/δ), and γ, in ES cells and its role in embryo development. In addition, pluripotent mouse ES cells can be expanded in large numbers in vitro due to the process of symmetrical self-renewal. Here we describe how PPARδ sustains ES cell proliferation.

KW - ES cells

KW - High glucose

KW - PPARδ

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Role of peroxisome proliferator-activated receptor (ppar)δ in embryonic stem cell proliferation

Abstract

Keywords

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