TY - JOUR
T1 - Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1 receptors in the brain
T2 - Neuroprotection versus neurotoxicity
AU - Kim, Sang R.
AU - Chung, Young C.
AU - Chung, Eun S.
AU - Park, Keun W.
AU - Won, So Y.
AU - Bok, E.
AU - Park, Eun S.
AU - Jin, Byung K.
PY - 2007/6
Y1 - 2007/6
N2 - Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Cannabinoid type 1 (CB1) receptor belongs to the G protein-coupled receptor superfamily and is activated by cannabinoids such as AEA and exogenous Δ-9-tetrahydrocannabinol (THC). TRPV1 and CB1 receptors are widely expressed in the brain and play many significant roles in various brain regions; however, the issue of whether TRPV1 or CB1 receptors mediate neuroprotection or neurotoxicity remains controversial. Furthermore, functional crosstalk between these two receptors has been recently reported. It is therefore timely to review current knowledge regarding the functions of these two receptors and to consider new directions of investigation on their roles in the brain.
AB - Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Cannabinoid type 1 (CB1) receptor belongs to the G protein-coupled receptor superfamily and is activated by cannabinoids such as AEA and exogenous Δ-9-tetrahydrocannabinol (THC). TRPV1 and CB1 receptors are widely expressed in the brain and play many significant roles in various brain regions; however, the issue of whether TRPV1 or CB1 receptors mediate neuroprotection or neurotoxicity remains controversial. Furthermore, functional crosstalk between these two receptors has been recently reported. It is therefore timely to review current knowledge regarding the functions of these two receptors and to consider new directions of investigation on their roles in the brain.
UR - http://www.scopus.com/inward/record.url?scp=36248931483&partnerID=8YFLogxK
U2 - 10.1007/s12035-007-0030-1
DO - 10.1007/s12035-007-0030-1
M3 - Review article
C2 - 17917113
AN - SCOPUS:36248931483
SN - 0893-7648
VL - 35
SP - 245
EP - 254
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 3
ER -