Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion

Tae Yong Shin; Hye Young Shin; Sang Hyun Kim; Dae Keun Kim; Byeong Suk Chae; Chan Ho Oh; Moon Gu Cho; Suk Heung Oh; Jong Hwa Kim; Tae Kyoo Lee; Jeong Suk Park

Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion

Tae Yong Shin, Hye Young Shin, Sang Hyun Kim, Dae Keun Kim, Byeong Suk Chae, Chan Ho Oh, Moon Gu Cho, Suk Heung Oh, Jong Hwa Kim, Tae Kyoo Lee, Jeong Suk Park

Department of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq. (Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

Original language	English
Pages (from-to)	144-149
Number of pages	6
Journal	Natural Product Sciences
Volume	12
Issue number	3
State	Published - Sep 2006

Keywords

Allergic reaction
Interleukin (IL)-6
Mast cells
Rubus coreanus
Tumor necrosis factor (TNF)-α

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion",

abstract = "The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq. (Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.",

keywords = "Allergic reaction, Interleukin (IL)-6, Mast cells, Rubus coreanus, Tumor necrosis factor (TNF)-α",

author = "Shin, {Tae Yong} and Shin, {Hye Young} and Kim, {Sang Hyun} and Kim, {Dae Keun} and Chae, {Byeong Suk} and Oh, {Chan Ho} and Cho, {Moon Gu} and Oh, {Suk Heung} and Kim, {Jong Hwa} and Lee, {Tae Kyoo} and Park, {Jeong Suk}",

year = "2006",

month = sep,

language = "English",

volume = "12",

pages = "144--149",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

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T1 - Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion

AU - Shin, Tae Yong

AU - Shin, Hye Young

AU - Kim, Sang Hyun

AU - Kim, Dae Keun

AU - Chae, Byeong Suk

AU - Oh, Chan Ho

AU - Cho, Moon Gu

AU - Oh, Suk Heung

AU - Kim, Jong Hwa

AU - Lee, Tae Kyoo

AU - Park, Jeong Suk

PY - 2006/9

Y1 - 2006/9

N2 - The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq. (Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

AB - The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq. (Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

KW - Allergic reaction

KW - Interleukin (IL)-6

KW - Mast cells

KW - Rubus coreanus

KW - Tumor necrosis factor (TNF)-α

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M3 - Article

AN - SCOPUS:33750212586

SN - 1226-3907

VL - 12

SP - 144

EP - 149

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 3

ER -

Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion

Abstract

Keywords

UN SDGs

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