Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion

Tae Yong Shin; Hye Young Shin; Sang Hyun Kim; Dae Keun Kim; Byeong Suk Chae; Chan Ho Oh; Moon Gu Cho; Suk Heung Oh; Jong Hwa Kim; Tae Kyoo Lee; Jeong Suk Park

Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion

Tae Yong Shin
, Hye Young Shin
, Sang Hyun Kim
, Dae Keun Kim
, Byeong Suk Chae
, Chan Ho Oh
, Moon Gu Cho
, Suk Heung Oh
, Jong Hwa Kim
, Tae Kyoo Lee
, Jeong Suk Park

Department of Medicine

Woosuk University
Nambu University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq. (Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

Original language	English
Pages (from-to)	144-149
Number of pages	6
Journal	Natural Product Sciences
Volume	12
Issue number	3
State	Published - Sep 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Allergic reaction
Interleukin (IL)-6
Mast cells
Rubus coreanus
Tumor necrosis factor (TNF)-α

Cite this

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title = "Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion",

abstract = "The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq. (Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.",

keywords = "Allergic reaction, Interleukin (IL)-6, Mast cells, Rubus coreanus, Tumor necrosis factor (TNF)-α",

author = "Shin, \{Tae Yong\} and Shin, \{Hye Young\} and Kim, \{Sang Hyun\} and Kim, \{Dae Keun\} and Chae, \{Byeong Suk\} and Oh, \{Chan Ho\} and Cho, \{Moon Gu\} and Oh, \{Suk Heung\} and Kim, \{Jong Hwa\} and Lee, \{Tae Kyoo\} and Park, \{Jeong Suk\}",

year = "2006",

month = sep,

language = "English",

volume = "12",

pages = "144--149",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

number = "3",

}

TY - JOUR

T1 - Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion

AU - Shin, Tae Yong

AU - Shin, Hye Young

AU - Kim, Sang Hyun

AU - Kim, Dae Keun

AU - Chae, Byeong Suk

AU - Oh, Chan Ho

AU - Cho, Moon Gu

AU - Oh, Suk Heung

AU - Kim, Jong Hwa

AU - Lee, Tae Kyoo

AU - Park, Jeong Suk

PY - 2006/9

Y1 - 2006/9

N2 - The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq. (Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

AB - The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq. (Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.

KW - Allergic reaction

KW - Interleukin (IL)-6

KW - Mast cells

KW - Rubus coreanus

KW - Tumor necrosis factor (TNF)-α

UR - https://www.scopus.com/pages/publications/33750212586

M3 - Article

AN - SCOPUS:33750212586

SN - 1226-3907

VL - 12

SP - 144

EP - 149

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 3

ER -

Rubus coreanus unripe fruits inhibits immediate-type allergic reaction and inflammatory cytokine secretion

Abstract

UN SDGs

Keywords

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