Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study

Leela Goel; Huaiyu Wu; Bohua Zhang; Jinwook Kim; Paul A. Dayton; Zhen Xu; Xiaoning Jiang

doi:10.1016/j.ultrasmedbio.2021.07.018

Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study

Leela Goel, Huaiyu Wu, Bohua Zhang, Jinwook Kim, Paul A. Dayton, Zhen Xu, Xiaoning Jiang

School of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Recent in vitro work has revealed that a forward-viewing intravascular (FVI) transducer has sonothrombolysis applications. However, the safety of this device has yet to be evaluated. In this study, we evaluated the safety of this device in terms of tissue heating, vessel damage and particle debris size during sonothrombolysis using microbubbles or nanodroplets with tissue plasminogen activator, in both retracted and unretracted blood clots. The in vitro and ex vivo sonothrombolysis tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm. These in vitro and ex vivo results indicate that the FVI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models.

Original language	English
Pages (from-to)	3231-3239
Number of pages	9
Journal	Ultrasound in Medicine and Biology
Volume	47
Issue number	11
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2021.07.018
State	Published - Nov 2021

Keywords

Intravascular sonothrombolysis
Microbubbles
Nanodroplets
Retracted clots
Safety
Tissue plasminogen activator
Ultrasound-assisted thrombolysis

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10.1016/j.ultrasmedbio.2021.07.018

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title = "Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study",

abstract = "Recent in vitro work has revealed that a forward-viewing intravascular (FVI) transducer has sonothrombolysis applications. However, the safety of this device has yet to be evaluated. In this study, we evaluated the safety of this device in terms of tissue heating, vessel damage and particle debris size during sonothrombolysis using microbubbles or nanodroplets with tissue plasminogen activator, in both retracted and unretracted blood clots. The in vitro and ex vivo sonothrombolysis tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm. These in vitro and ex vivo results indicate that the FVI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models.",

keywords = "Intravascular sonothrombolysis, Microbubbles, Nanodroplets, Retracted clots, Safety, Tissue plasminogen activator, Ultrasound-assisted thrombolysis",

author = "Leela Goel and Huaiyu Wu and Bohua Zhang and Jinwook Kim and Dayton, {Paul A.} and Zhen Xu and Xiaoning Jiang",

note = "Publisher Copyright: {\textcopyright} 2021 World Federation for Ultrasound in Medicine & Biology",

year = "2021",

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doi = "10.1016/j.ultrasmedbio.2021.07.018",

language = "English",

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T2 - An in Vitro and ex Vivo Study

AU - Goel, Leela

AU - Wu, Huaiyu

AU - Zhang, Bohua

AU - Kim, Jinwook

AU - Dayton, Paul A.

AU - Xu, Zhen

AU - Jiang, Xiaoning

PY - 2021/11

Y1 - 2021/11

N2 - Recent in vitro work has revealed that a forward-viewing intravascular (FVI) transducer has sonothrombolysis applications. However, the safety of this device has yet to be evaluated. In this study, we evaluated the safety of this device in terms of tissue heating, vessel damage and particle debris size during sonothrombolysis using microbubbles or nanodroplets with tissue plasminogen activator, in both retracted and unretracted blood clots. The in vitro and ex vivo sonothrombolysis tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm. These in vitro and ex vivo results indicate that the FVI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models.

AB - Recent in vitro work has revealed that a forward-viewing intravascular (FVI) transducer has sonothrombolysis applications. However, the safety of this device has yet to be evaluated. In this study, we evaluated the safety of this device in terms of tissue heating, vessel damage and particle debris size during sonothrombolysis using microbubbles or nanodroplets with tissue plasminogen activator, in both retracted and unretracted blood clots. The in vitro and ex vivo sonothrombolysis tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm. These in vitro and ex vivo results indicate that the FVI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models.

KW - Intravascular sonothrombolysis

KW - Microbubbles

KW - Nanodroplets

KW - Retracted clots

KW - Safety

KW - Tissue plasminogen activator

KW - Ultrasound-assisted thrombolysis

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DO - 10.1016/j.ultrasmedbio.2021.07.018

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JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 11

ER -

Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study

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Keywords

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