Sanguisorba officinalis inhibits immediate-type allergic reactions

Sung Hwa Kim, Dae Keun Kim, Dong Ok Eom, Sang Yong Kim, Sang Hyun Kim, Tae Yong Shin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The effect of aqueous extract of Sanguisorba officinalis L. (Rosaceae) root (SOAE) on the immediate-type allergic reactions by anal therapy was investigated. SOAE (0.01 to 1 g/kg) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. When SOAE was pretreated at the same concentrations with systemic anaphylaxis, the plasma histamine levels were reduced in a dose-dependent manner. SOAE (0.1 and 1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. SOAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cyclic AMP (cAMP) in RPMC, when SOAE (1 mg/ml) was added, transiently and significantly increased compared with that of basal cells. These results provide evidence that anal therapy of SOAE may be beneficial in the treatment of allergic diseases.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalNatural Product Sciences
Issue number4
StatePublished - Dec 2002


  • Anal therapy
  • Anaphylaxis
  • Anti-DNP IgE
  • Compound 48/80
  • Cyclic AMP
  • Histamine
  • Sanguisorba officinalis


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