Scutellaria radix Extract as a Natural UV Protectant for Human Skin

Jin Kyung Seok; Jun Yup Kwak; Go Woon Choi; Sang Mi An; Jae Hoon Kwak; Hyeong Ho Seo; Hwa Jin Suh; Yong Chool Boo

doi:10.1002/ptr.5534

Scutellaria radix Extract as a Natural UV Protectant for Human Skin

Jin Kyung Seok, Jun Yup Kwak, Go Woon Choi, Sang Mi An, Jae Hoon Kwak, Hyeong Ho Seo, Hwa Jin Suh, Yong Chool Boo

Department of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Ultraviolet (UV) radiation induces oxidative injury and inflammation in human skin. Scutellaria radix (SR, the root of Scutellaria baicalensis Georgi) contains flavonoids with high UV absorptivity and antioxidant properties. The purpose of this study was to examine the potential use of SR extract as an additive in cosmetic products for UV protection. SR extract and its butanol (BuOH) fraction strongly absorbed UV radiation and displayed free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radials and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radicals. They also attenuated the UV-induced death of HaCaT cells. Sunscreen creams, with or without supplementation of SR extract BuOH fraction, were tested in vivo in human trials to evaluate potential skin irritation and determine the sun protection factor (SPF). Both sunscreen creams induced no skin irritation. A sunscreen cream containing 24% ZnO showed an SPF value of 17.8, and it increased to 22.7 when supplemented with 5% SR extract BuOH fraction. This study suggests that SR-derived materials are useful as safe cosmetic additives that provide UV protection.

Original language	English
Pages (from-to)	374-379
Number of pages	6
Journal	Phytotherapy Research
Volume	30
Issue number	3
DOIs	https://doi.org/10.1002/ptr.5534
State	Published - 1 Mar 2016

Keywords

human skin
oxidative stress
Scutellaria baicalensis Georgi
sun protection factor
ultraviolet

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title = "Scutellaria radix Extract as a Natural UV Protectant for Human Skin",

abstract = "Ultraviolet (UV) radiation induces oxidative injury and inflammation in human skin. Scutellaria radix (SR, the root of Scutellaria baicalensis Georgi) contains flavonoids with high UV absorptivity and antioxidant properties. The purpose of this study was to examine the potential use of SR extract as an additive in cosmetic products for UV protection. SR extract and its butanol (BuOH) fraction strongly absorbed UV radiation and displayed free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radials and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radicals. They also attenuated the UV-induced death of HaCaT cells. Sunscreen creams, with or without supplementation of SR extract BuOH fraction, were tested in vivo in human trials to evaluate potential skin irritation and determine the sun protection factor (SPF). Both sunscreen creams induced no skin irritation. A sunscreen cream containing 24% ZnO showed an SPF value of 17.8, and it increased to 22.7 when supplemented with 5% SR extract BuOH fraction. This study suggests that SR-derived materials are useful as safe cosmetic additives that provide UV protection.",

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author = "Seok, {Jin Kyung} and Kwak, {Jun Yup} and Choi, {Go Woon} and An, {Sang Mi} and Kwak, {Jae Hoon} and Seo, {Hyeong Ho} and Suh, {Hwa Jin} and Boo, {Yong Chool}",

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AU - Seo, Hyeong Ho

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AU - Boo, Yong Chool

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Scutellaria radix Extract as a Natural UV Protectant for Human Skin

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