Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo

Jungwook Chin; Jun Young Hong; Jaehwan Lee; Hoosang Hwang; Hyunsil Ko; Hyukjae Choi; Dongyup Hahn; Jaeyoung Ko; Sang Jip Nam; Jungae Tak; Jungyeob Ham; Heonjoong Kang

doi:10.1016/j.bmcl.2010.10.103

Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo

Jungwook Chin, Jun Young Hong, Jaehwan Lee, Hoosang Hwang, Hyunsil Ko, Hyukjae Choi, Dongyup Hahn, Jaeyoung Ko, Sang Jip Nam, Jungae Tak, Jungyeob Ham, Heonjoong Kang

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We report the synthesis and in vivo activity of a novel anti-atherogenic agent, isosteric selenium PPARδ-selective ligand. This ligand did not cause significant body or liver weight changes and did not have obvious adverse effects on intestinal polyp formation. Our overall results clearly demonstrate that PPARδ is a viable drug candidate for targeting and treating atherosclerosis.

Original language	English
Pages (from-to)	7239-7242
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2010.10.103
State	Published - 15 Dec 2010

Keywords

Anti-atherogenic agents
Intestinal polyp formation
PPARδ-selective ligand

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10.1016/j.bmcl.2010.10.103

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abstract = "We report the synthesis and in vivo activity of a novel anti-atherogenic agent, isosteric selenium PPARδ-selective ligand. This ligand did not cause significant body or liver weight changes and did not have obvious adverse effects on intestinal polyp formation. Our overall results clearly demonstrate that PPARδ is a viable drug candidate for targeting and treating atherosclerosis.",

keywords = "Anti-atherogenic agents, Intestinal polyp formation, PPARδ-selective ligand",

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doi = "10.1016/j.bmcl.2010.10.103",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo

AU - Chin, Jungwook

AU - Hong, Jun Young

AU - Lee, Jaehwan

AU - Hwang, Hoosang

AU - Ko, Hyunsil

AU - Choi, Hyukjae

AU - Hahn, Dongyup

AU - Ko, Jaeyoung

AU - Nam, Sang Jip

AU - Tak, Jungae

AU - Ham, Jungyeob

AU - Kang, Heonjoong

PY - 2010/12/15

Y1 - 2010/12/15

N2 - We report the synthesis and in vivo activity of a novel anti-atherogenic agent, isosteric selenium PPARδ-selective ligand. This ligand did not cause significant body or liver weight changes and did not have obvious adverse effects on intestinal polyp formation. Our overall results clearly demonstrate that PPARδ is a viable drug candidate for targeting and treating atherosclerosis.

AB - We report the synthesis and in vivo activity of a novel anti-atherogenic agent, isosteric selenium PPARδ-selective ligand. This ligand did not cause significant body or liver weight changes and did not have obvious adverse effects on intestinal polyp formation. Our overall results clearly demonstrate that PPARδ is a viable drug candidate for targeting and treating atherosclerosis.

KW - Anti-atherogenic agents

KW - Intestinal polyp formation

KW - PPARδ-selective ligand

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U2 - 10.1016/j.bmcl.2010.10.103

DO - 10.1016/j.bmcl.2010.10.103

M3 - Article

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AN - SCOPUS:78449273353

SN - 0960-894X

VL - 20

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EP - 7242

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo

Abstract

Keywords

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