Sensing viral invasion by RIG-I like receptors

Ji Seung Yoo; Hiroki Kato; Takashi Fujita

doi:10.1016/j.mib.2014.05.011

Sensing viral invasion by RIG-I like receptors

Ji Seung Yoo
, Hiroki Kato
, Takashi Fujita

Kyoto University

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invasion. RLRs recognize cytoplasmic viral RNAs and trigger antiviral responses, resulting in production of type I IFN and inflammatory cytokines. Unique and common sensing mechanisms among RLRs have been reported. In this review, recent progress in the understanding of antiviral responses by RLRs is summarized and discussed.

Original language	English
Pages (from-to)	131-138
Number of pages	8
Journal	Current Opinion in Microbiology
Volume	20
DOIs	https://doi.org/10.1016/j.mib.2014.05.011
State	Published - Aug 2014

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10.1016/j.mib.2014.05.011

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title = "Sensing viral invasion by RIG-I like receptors",

abstract = "Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invasion. RLRs recognize cytoplasmic viral RNAs and trigger antiviral responses, resulting in production of type I IFN and inflammatory cytokines. Unique and common sensing mechanisms among RLRs have been reported. In this review, recent progress in the understanding of antiviral responses by RLRs is summarized and discussed.",

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AU - Yoo, Ji Seung

AU - Kato, Hiroki

AU - Fujita, Takashi

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N2 - Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invasion. RLRs recognize cytoplasmic viral RNAs and trigger antiviral responses, resulting in production of type I IFN and inflammatory cytokines. Unique and common sensing mechanisms among RLRs have been reported. In this review, recent progress in the understanding of antiviral responses by RLRs is summarized and discussed.

AB - Cellular responses to pathogen invasion are crucial for maintaining cell homeostasis and survival. The interferon (IFN) system is one of the most effective cellular responses to viral intrusion in mammals. Viral recognition by innate immune sensors activates the antiviral IFN system. Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) are DExD/H box RNA helicases that sense viral invasion. RLRs recognize cytoplasmic viral RNAs and trigger antiviral responses, resulting in production of type I IFN and inflammatory cytokines. Unique and common sensing mechanisms among RLRs have been reported. In this review, recent progress in the understanding of antiviral responses by RLRs is summarized and discussed.

UR - https://www.scopus.com/pages/publications/84902951706

U2 - 10.1016/j.mib.2014.05.011

DO - 10.1016/j.mib.2014.05.011

M3 - Review article

C2 - 24968321

AN - SCOPUS:84902951706

SN - 1369-5274

VL - 20

SP - 131

EP - 138

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

ER -

Sensing viral invasion by RIG-I like receptors

Abstract

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