Sertoli cell tumor (SCT) in a captive black bear (Ursus americanus)

Ahmed K. Elfadl; Sun Young Park; H. M. Arif Ullah; Soong Hee Youn; Myung Jin Chung; Ji Yoon Son; Jae Yeong Lee; Seoung Woo Lee; A. Rang Lee; Su Min Baek; Sul Gi Jeon; Eun Joo Lee; Il Hwa Hong; Jin Kyu Park; Kyu Shik Jeong

doi:10.3390/vetsci6040077

Sertoli cell tumor (SCT) in a captive black bear (Ursus americanus)

Ahmed K. Elfadl, Sun Young Park, H. M. Arif Ullah, Soong Hee Youn, Myung Jin Chung, Ji Yoon Son, Jae Yeong Lee, Seoung Woo Lee, A. Rang Lee, Su Min Baek, Sul Gi Jeon, Eun Joo Lee, Il Hwa Hong, Jin Kyu Park, Kyu Shik Jeong

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Abstract

A black bear of 29-year-old (Ursus americanus) died unexpectedly in captivity without any gross lesions or clinical signs. We identified a firm, lobulated, yellowish tan, and well-circumscribed mass embedded inside the testicular tissue at the time of necropsy. The tumor sections exhibited soft necrotic and hemorrhagic areas beneath its capsule. Histologically, the tumor comprised Sertoli cells arranged in tubules and solid sheets supported by prominent fibrous connective tissues. The Sertoli cells were positive for vimentin and ER-β expression, whereas it showed negative staining for inhibin-α, cytokeratin 19, and S-100. To the best of our knowledge, this is the rare case report of testicular Sertoli cell tumor in black bear.

Original language	English
Article number	77
Journal	Veterinary Sciences
Volume	6
Issue number	4
DOIs	https://doi.org/10.3390/vetsci6040077
State	Published - 2019

Keywords

Neoplasm
Sertoli cells
Testes
Ursidae
Vimentin

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@article{232e8031a1724e6bb32a41d1d5ba10f7,

title = "Sertoli cell tumor (SCT) in a captive black bear (Ursus americanus)",

abstract = "A black bear of 29-year-old (Ursus americanus) died unexpectedly in captivity without any gross lesions or clinical signs. We identified a firm, lobulated, yellowish tan, and well-circumscribed mass embedded inside the testicular tissue at the time of necropsy. The tumor sections exhibited soft necrotic and hemorrhagic areas beneath its capsule. Histologically, the tumor comprised Sertoli cells arranged in tubules and solid sheets supported by prominent fibrous connective tissues. The Sertoli cells were positive for vimentin and ER-β expression, whereas it showed negative staining for inhibin-α, cytokeratin 19, and S-100. To the best of our knowledge, this is the rare case report of testicular Sertoli cell tumor in black bear.",

keywords = "Neoplasm, Sertoli cells, Testes, Ursidae, Vimentin",

author = "Elfadl, {Ahmed K.} and Park, {Sun Young} and {Arif Ullah}, {H. M.} and Youn, {Soong Hee} and Chung, {Myung Jin} and Son, {Ji Yoon} and Lee, {Jae Yeong} and Lee, {Seoung Woo} and Lee, {A. Rang} and Baek, {Su Min} and Jeon, {Sul Gi} and Lee, {Eun Joo} and Hong, {Il Hwa} and Park, {Jin Kyu} and Jeong, {Kyu Shik}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors.",

year = "2019",

doi = "10.3390/vetsci6040077",

language = "English",

volume = "6",

journal = "Veterinary Sciences",

issn = "2306-7381",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Sertoli cell tumor (SCT) in a captive black bear (Ursus americanus)

AU - Elfadl, Ahmed K.

AU - Park, Sun Young

AU - Arif Ullah, H. M.

AU - Youn, Soong Hee

AU - Chung, Myung Jin

AU - Son, Ji Yoon

AU - Lee, Jae Yeong

AU - Lee, Seoung Woo

AU - Lee, A. Rang

AU - Baek, Su Min

AU - Jeon, Sul Gi

AU - Lee, Eun Joo

AU - Hong, Il Hwa

AU - Park, Jin Kyu

AU - Jeong, Kyu Shik

PY - 2019

Y1 - 2019

N2 - A black bear of 29-year-old (Ursus americanus) died unexpectedly in captivity without any gross lesions or clinical signs. We identified a firm, lobulated, yellowish tan, and well-circumscribed mass embedded inside the testicular tissue at the time of necropsy. The tumor sections exhibited soft necrotic and hemorrhagic areas beneath its capsule. Histologically, the tumor comprised Sertoli cells arranged in tubules and solid sheets supported by prominent fibrous connective tissues. The Sertoli cells were positive for vimentin and ER-β expression, whereas it showed negative staining for inhibin-α, cytokeratin 19, and S-100. To the best of our knowledge, this is the rare case report of testicular Sertoli cell tumor in black bear.

AB - A black bear of 29-year-old (Ursus americanus) died unexpectedly in captivity without any gross lesions or clinical signs. We identified a firm, lobulated, yellowish tan, and well-circumscribed mass embedded inside the testicular tissue at the time of necropsy. The tumor sections exhibited soft necrotic and hemorrhagic areas beneath its capsule. Histologically, the tumor comprised Sertoli cells arranged in tubules and solid sheets supported by prominent fibrous connective tissues. The Sertoli cells were positive for vimentin and ER-β expression, whereas it showed negative staining for inhibin-α, cytokeratin 19, and S-100. To the best of our knowledge, this is the rare case report of testicular Sertoli cell tumor in black bear.

KW - Neoplasm

KW - Sertoli cells

KW - Testes

KW - Ursidae

KW - Vimentin

UR - http://www.scopus.com/inward/record.url?scp=85076703139&partnerID=8YFLogxK

U2 - 10.3390/vetsci6040077

DO - 10.3390/vetsci6040077

M3 - Article

AN - SCOPUS:85076703139

SN - 2306-7381

VL - 6

JO - Veterinary Sciences

JF - Veterinary Sciences

IS - 4

M1 - 77

ER -

Sertoli cell tumor (SCT) in a captive black bear (Ursus americanus)

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Keywords

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