Serum levels of PCSK9 are associated with coronary angiographic severity in patients with acute coronary syndrome

Kwi Hyun Bae, Sung Woo Kim, Yeon Kyung Choi, Jung Beom Seo, Namkyun Kim, Chang Yeon Kim, Won Kee Lee, Sungwoo Lee, Jung Guk Kim, In Kyu Lee, Jang Hoon Lee, Keun Gyu Park

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown. Methods: From December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study. Serum levels of PCSK9 and metabolic parameters were measured. SYNTAX (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) and GRACE (Global Registry of Acute Coronary Events) scores were calculated. Results: Individuals with CAG lesions (n=100) had significantly higher levels of PCSK9 than those without lesions (n=21). The study population was stratified into three groups according to serum levels of PCSK9. The odds radio for occurrence of one or more CAG lesions was significantly higher in the group with the highest level of PCSK9 (odds ratio, 7.468; P=0.011) than in the group with the lowest level of PCSK9. Serum PCSK9 was positively associated with the number of involved coronary arteries. Multivariable linear regression indicated that levels of PCSK9 were positively correlated with GRACE risk scores and SYNTAX scores. Conclusion: Serum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease.

Original languageEnglish
Pages (from-to)207-214
Number of pages8
JournalDiabetes and Metabolism Journal
Volume42
Issue number3
DOIs
StatePublished - 1 Jun 2018

Keywords

  • Cardiovascular diseases
  • Coronary angiography
  • Proprotein convertase 9

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