Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation

Hyun Jae Jang; Jin Han Kim; Hyun Mee Oh; Min Suk Kim; Jin Ha Jo; Kyungsook Jung; Soyoung Lee; Young Ho Kim; Woo Song Lee; Seung Woong Lee; Mun Chual Rho

doi:10.1248/cpb.c16-00086

Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation

Hyun Jae Jang, Jin Han Kim, Hyun Mee Oh, Min Suk Kim, Jin Ha Jo, Kyungsook Jung, Soyoung Lee, Young Ho Kim, Woo Song Lee, Seung Woong Lee, Mun Chual Rho

Department of Innovative Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.

Original language	English
Pages (from-to)	1062-1066
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	64
Issue number	7
DOIs	https://doi.org/10.1248/cpb.c16-00086
State	Published - 2016

Keywords

Curcuma phaeocaulis
Lipopolysaccharide (LPS)
Sesquiterpenoid
Toll-like receptor 4 (TLR4)
Zingiberaceae

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10.1248/cpb.c16-00086

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title = "Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation",

abstract = "Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.",

keywords = "Curcuma phaeocaulis, Lipopolysaccharide (LPS), Sesquiterpenoid, Toll-like receptor 4 (TLR4), Zingiberaceae",

author = "Jang, {Hyun Jae} and Kim, {Jin Han} and Oh, {Hyun Mee} and Kim, {Min Suk} and Jo, {Jin Ha} and Kyungsook Jung and Soyoung Lee and Kim, {Young Ho} and Lee, {Woo Song} and Lee, {Seung Woong} and Rho, {Mun Chual}",

note = "Publisher Copyright: {\textcopyright} 2016 The Pharmaceutical Society of Japan.",

year = "2016",

doi = "10.1248/cpb.c16-00086",

language = "English",

volume = "64",

pages = "1062--1066",

journal = "Chemical and Pharmaceutical Bulletin",

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AU - Jang, Hyun Jae

AU - Kim, Jin Han

AU - Oh, Hyun Mee

AU - Kim, Min Suk

AU - Jo, Jin Ha

AU - Jung, Kyungsook

AU - Lee, Soyoung

AU - Kim, Young Ho

AU - Lee, Woo Song

AU - Lee, Seung Woong

AU - Rho, Mun Chual

PY - 2016

Y1 - 2016

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AB - Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.

KW - Curcuma phaeocaulis

KW - Lipopolysaccharide (LPS)

KW - Sesquiterpenoid

KW - Toll-like receptor 4 (TLR4)

KW - Zingiberaceae

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U2 - 10.1248/cpb.c16-00086

DO - 10.1248/cpb.c16-00086

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AN - SCOPUS:84978039285

SN - 0009-2363

VL - 64

SP - 1062

EP - 1066

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 7

ER -

Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation

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Keywords

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