Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation

Hyun Jae Jang; Jin Han Kim; Hyun Mee Oh; Min Suk Kim; Jin Ha Jo; Kyungsook Jung; Soyoung Lee; Young Ho Kim; Woo Song Lee; Seung Woong Lee; Mun Chual Rho

doi:10.1248/cpb.c16-00086

Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation

Hyun Jae Jang
, Jin Han Kim
, Hyun Mee Oh
, Min Suk Kim
, Jin Ha Jo
, Kyungsook Jung
, Soyoung Lee
, Young Ho Kim
, Woo Song Lee
, Seung Woong Lee
, Mun Chual Rho

Department of Innovative Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.

Original language	English
Pages (from-to)	1062-1066
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	64
Issue number	7
DOIs	https://doi.org/10.1248/cpb.c16-00086
State	Published - 2016

Keywords

Curcuma phaeocaulis
Lipopolysaccharide (LPS)
Sesquiterpenoid
Toll-like receptor 4 (TLR4)
Zingiberaceae

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10.1248/cpb.c16-00086

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title = "Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation",

abstract = "Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.",

keywords = "Curcuma phaeocaulis, Lipopolysaccharide (LPS), Sesquiterpenoid, Toll-like receptor 4 (TLR4), Zingiberaceae",

author = "Jang, \{Hyun Jae\} and Kim, \{Jin Han\} and Oh, \{Hyun Mee\} and Kim, \{Min Suk\} and Jo, \{Jin Ha\} and Kyungsook Jung and Soyoung Lee and Kim, \{Young Ho\} and Lee, \{Woo Song\} and Lee, \{Seung Woong\} and Rho, \{Mun Chual\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Pharmaceutical Society of Japan.",

year = "2016",

doi = "10.1248/cpb.c16-00086",

language = "English",

volume = "64",

pages = "1062--1066",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

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TY - JOUR

T1 - Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation

AU - Jang, Hyun Jae

AU - Kim, Jin Han

AU - Oh, Hyun Mee

AU - Kim, Min Suk

AU - Jo, Jin Ha

AU - Jung, Kyungsook

AU - Lee, Soyoung

AU - Kim, Young Ho

AU - Lee, Woo Song

AU - Lee, Seung Woong

AU - Rho, Mun Chual

PY - 2016

Y1 - 2016

N2 - Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.

AB - Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.

KW - Curcuma phaeocaulis

KW - Lipopolysaccharide (LPS)

KW - Sesquiterpenoid

KW - Toll-like receptor 4 (TLR4)

KW - Zingiberaceae

UR - https://www.scopus.com/pages/publications/84978039285

U2 - 10.1248/cpb.c16-00086

DO - 10.1248/cpb.c16-00086

M3 - Article

C2 - 27373668

AN - SCOPUS:84978039285

SN - 0009-2363

VL - 64

SP - 1062

EP - 1066

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 7

ER -

Sesquiterpenoids from the rhizomes of Curcuma phaeocaulis and their inhibitory effects on LPS-induced TLR4 activation

Abstract

Keywords

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