Severe Acute Respiratory Syndrome Coronavirus-2 Antibody Responses in Hospitalized Patients with Coronavirus Disease 2019 in Daegu, Korea

Yu Kyung Kim, Dohsik Minn, Eun Hyung Yoo, Mikyoung Park, Jae Hee Lee, Jung Sook Ha, Ji Yeon Ham, Soon Hee Chang, Hyun Chul Lee, Jang Soo Suh, Chang Ho Jeon, Do Hoon Kim, Sunggyun Park, Nan Young Lee, Kyung Eun Song, Soohyun Kim, Tae Yeob Kim, Sang Gyung Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) started to spread in Daegu beginning at the end of February 2020. IgG and IgM antibodies against SARS-CoV-2 were measured in hospitalized patients with COVID-19 with moderate to severe symptoms to im-prove the understanding of antibody responses. Methods: We enrolled 312 patients with COVID-19 admitted to seven hospitals located in Daegu. Using serum (or plasma) samples from patients with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infections, both IgG and IgM antibodies were measured using commercial enzyme-linked immunosorbent assay (R-FIND CO-VID-19 ELISA, SG medical, Seoul, Korea). Results: The median value from the initial diagnosis, confirmed by SARS-CoV-2 PCR, to the sampling date was 24 days (day 1 to 88). The total positive rate of IgG was 93.9% and the positive IgM rate was 39.4%, without consid-ering the elapsed period after diagnosis. Positive IgG and IgM rates were highest at 100.0% and 59.0%, respec-tively, at 3 weeks (15 - 21 days). IgG showed a high positive rate of 79.3% even within 7 days after the initial diag-nosis of the disease and maintained a positive rate of 97.8% until after 8 weeks. Conclusions: Among hospitalized patients with COVID-19, IgG was detected from the beginning of the diagnosis and persisted for an extended time period.

Original languageEnglish
Pages (from-to)2533-2539
Number of pages7
JournalClinical Laboratory
Volume67
Issue number11
DOIs
StatePublished - 2021

Keywords

  • Antibody re-sponse
  • COVID-19
  • ELISA
  • SARS-CoV-2 PCR

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