Abstract
Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) started to spread in Daegu beginning at the end of February 2020. IgG and IgM antibodies against SARS-CoV-2 were measured in hospitalized patients with COVID-19 with moderate to severe symptoms to im-prove the understanding of antibody responses. Methods: We enrolled 312 patients with COVID-19 admitted to seven hospitals located in Daegu. Using serum (or plasma) samples from patients with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infections, both IgG and IgM antibodies were measured using commercial enzyme-linked immunosorbent assay (R-FIND CO-VID-19 ELISA, SG medical, Seoul, Korea). Results: The median value from the initial diagnosis, confirmed by SARS-CoV-2 PCR, to the sampling date was 24 days (day 1 to 88). The total positive rate of IgG was 93.9% and the positive IgM rate was 39.4%, without consid-ering the elapsed period after diagnosis. Positive IgG and IgM rates were highest at 100.0% and 59.0%, respec-tively, at 3 weeks (15 - 21 days). IgG showed a high positive rate of 79.3% even within 7 days after the initial diag-nosis of the disease and maintained a positive rate of 97.8% until after 8 weeks. Conclusions: Among hospitalized patients with COVID-19, IgG was detected from the beginning of the diagnosis and persisted for an extended time period.
Original language | English |
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Pages (from-to) | 2533-2539 |
Number of pages | 7 |
Journal | Clinical Laboratory |
Volume | 67 |
Issue number | 11 |
DOIs | |
State | Published - 2021 |
Keywords
- Antibody re-sponse
- COVID-19
- ELISA
- SARS-CoV-2 PCR