TY - JOUR
T1 - Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer
AU - Yu, Ji Eun
AU - Yeo, In Jun
AU - Han, Sang Bae
AU - Yun, Jaesuk
AU - Kim, Bongcheol
AU - Yong, Yoon Ji
AU - Lim, Young soo
AU - Kim, Tae Hun
AU - Son, Dong Ju
AU - Hong, Jin Tae
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024/2
Y1 - 2024/2
N2 - Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various inflammatory and immunological diseases, including several cancers, Alzheimer’s disease, and atherosclerosis. Several studies have shown that CHI3L1 can be considered as a marker of disease diagnosis, prognosis, disease activity, and severity. In addition, the proinflammatory action of CHI3L1 may be mediated via responses to various proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ. Therefore, CHI3L1 may contribute to a vast array of inflammatory diseases. However, its pathophysiological and pharmacological roles in the development of inflammatory diseases remain unclear. In this article, we review recent findings regarding the roles of CHI3L1 in the development of inflammatory diseases and suggest therapeutic approaches that target CHI3L1.
AB - Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various inflammatory and immunological diseases, including several cancers, Alzheimer’s disease, and atherosclerosis. Several studies have shown that CHI3L1 can be considered as a marker of disease diagnosis, prognosis, disease activity, and severity. In addition, the proinflammatory action of CHI3L1 may be mediated via responses to various proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ. Therefore, CHI3L1 may contribute to a vast array of inflammatory diseases. However, its pathophysiological and pharmacological roles in the development of inflammatory diseases remain unclear. In this article, we review recent findings regarding the roles of CHI3L1 in the development of inflammatory diseases and suggest therapeutic approaches that target CHI3L1.
UR - http://www.scopus.com/inward/record.url?scp=85181450477&partnerID=8YFLogxK
U2 - 10.1038/s12276-023-01131-9
DO - 10.1038/s12276-023-01131-9
M3 - Review article
C2 - 38177294
AN - SCOPUS:85181450477
SN - 1226-3613
VL - 56
SP - 1
EP - 18
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 1
ER -
