Abstract
Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by hapten-specific immune response. Silkworm droppings are known to exert beneficial effects during the treatment of inflammatory diseases. Here, we studied whether topical treatment and oral administration of silkworm dropping extract (SDE) ameliorate trimellitic anhydride (TMA)induced ACD. In ACD mice model, SDE treatment significantly suppressed the increase in both ear thickness and serum IgE levels. Furthermore, IL-1β and TNF-α levels were reduced by SDE. In allergic responses, SDE treatment significantly attenuated the production of the Th2-associated cytokine IL-4 in both ear tissue and draining lymph nodes. However, it increased the production of the Th1-mediated cytokine IL-12. Thus, these results showed that SDE attenuated TMA-induced ACD symptoms through regulation of Th1/Th2 immune response. Taken together, we suggest that SDE treatment might be a potential agent in the prevention or therapy of Th2-mediated inflammatory skin diseases such as ACD and atopic dermatitis.
Original language | English |
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Pages (from-to) | 1531-1538 |
Number of pages | 8 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 82 |
Issue number | 9 |
DOIs | |
State | Published - 2018 |
Keywords
- Allergic contact dermatitis
- Allergic inflammation
- Silkworm dropping extract
- Th1/Th2 immune balance
- Trimellitic anhydride