Silkworm dropping extract ameliorate trimellitic anhydride-induced allergic contact dermatitis by regulating Th1/Th2 immune response

Dae Woon Choi, Da Ae Kwon, Sung Keun Jung, Hye Jeong See, Sun Young Jung, Dong Hwa Shon, Hee Soon Shin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by hapten-specific immune response. Silkworm droppings are known to exert beneficial effects during the treatment of inflammatory diseases. Here, we studied whether topical treatment and oral administration of silkworm dropping extract (SDE) ameliorate trimellitic anhydride (TMA)induced ACD. In ACD mice model, SDE treatment significantly suppressed the increase in both ear thickness and serum IgE levels. Furthermore, IL-1β and TNF-α levels were reduced by SDE. In allergic responses, SDE treatment significantly attenuated the production of the Th2-associated cytokine IL-4 in both ear tissue and draining lymph nodes. However, it increased the production of the Th1-mediated cytokine IL-12. Thus, these results showed that SDE attenuated TMA-induced ACD symptoms through regulation of Th1/Th2 immune response. Taken together, we suggest that SDE treatment might be a potential agent in the prevention or therapy of Th2-mediated inflammatory skin diseases such as ACD and atopic dermatitis.

Original languageEnglish
Pages (from-to)1531-1538
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume82
Issue number9
DOIs
StatePublished - 2018

Keywords

  • Allergic contact dermatitis
  • Allergic inflammation
  • Silkworm dropping extract
  • Th1/Th2 immune balance
  • Trimellitic anhydride

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