Size-controlled one-pot polyol synthesis and characterization of D-glucuronic acid-coated ultrasmall BiOI nanoparticles as potential x-ray contrast agent

Adibehalsadat Ghazanfari, Ki Hye Jung, Ji Ae Park, Shanti Marasini, Son Long Ho, Xu Miao, Mohammad Yaseen Ahmad, Huan Yue, Seungbok Yang, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A polyol method is extremely useful for preparimg metal-containing nanoparticles coated with hydrophilic and biocompatible ligands for biomedical applications. In this study, D-glucuronic acid-coated BiOI nanoparticles were prepared in one-pot using this method. The particle diameter was controlled by varying the solvent volume such that the particle diameter decreased with increasing solvent volume: nanoparticles with average diameters of 1.9 (ultrasmall) and 6.1 nm were prepared at two solvent volumes. The x-ray attenuation properties of the ultrasmall nanoparticles were investigated because of their suitability for in vivo biomedical applications. D-glucuronic acid-coated ultrasmall BiOI nanoparticles were superior to the commercial molecular iodine contrast agent Ultravist® in terms of x-ray attenuation, and showed the highest x-ray attenuation efficiency (η) of ∼21 HU/mM [Bi] that has ever been reported thus far, proving their potential as an extremely powerful x-ray contrast agent.

Original languageEnglish
Article number015039
JournalMaterials Research Express
Volume6
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • BiOI
  • contrast agent
  • polyol method
  • ultrasmall nanoparticle
  • x-ray attenuation

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