Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Keonwook Nam; Taehyung Kim; Young Min Kim; Kyungjik Yang; Deokyoung Choe; Lawrence B. Mensah; Ki Young Choi; Young Hoon Roh

doi:10.1039/c9cc01442j

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Keonwook Nam, Taehyung Kim, Young Min Kim, Kyungjik Yang, Deokyoung Choe, Lawrence B. Mensah, Ki Young Choi, Young Hoon Roh

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

Original language	English
Pages (from-to)	4905-4908
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	34
DOIs	https://doi.org/10.1039/c9cc01442j
State	Published - 2019

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title = "Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery",

abstract = "We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.",

author = "Keonwook Nam and Taehyung Kim and Kim, {Young Min} and Kyungjik Yang and Deokyoung Choe and Mensah, {Lawrence B.} and Choi, {Ki Young} and Roh, {Young Hoon}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2019.",

year = "2019",

doi = "10.1039/c9cc01442j",

language = "English",

volume = "55",

pages = "4905--4908",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

AU - Nam, Keonwook

AU - Kim, Taehyung

AU - Kim, Young Min

AU - Yang, Kyungjik

AU - Choe, Deokyoung

AU - Mensah, Lawrence B.

AU - Choi, Ki Young

AU - Roh, Young Hoon

PY - 2019

Y1 - 2019

N2 - We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

AB - We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

UR - http://www.scopus.com/inward/record.url?scp=85065112772&partnerID=8YFLogxK

U2 - 10.1039/c9cc01442j

DO - 10.1039/c9cc01442j

M3 - Article

C2 - 30901006

AN - SCOPUS:85065112772

SN - 1359-7345

VL - 55

SP - 4905

EP - 4908

JO - Chemical Communications

JF - Chemical Communications

IS - 34

ER -

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Abstract

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