Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Keonwook Nam; Taehyung Kim; Young Min Kim; Kyungjik Yang; Deokyoung Choe; Lawrence B. Mensah; Ki Young Choi; Young Hoon Roh

doi:10.1039/c9cc01442j

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Keonwook Nam
, Taehyung Kim
, Young Min Kim
, Kyungjik Yang
, Deokyoung Choe
, Lawrence B. Mensah
, Ki Young Choi
, Young Hoon Roh

Yonsei University
Massachusetts Institute of Technology
Korea Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

Original language	English
Pages (from-to)	4905-4908
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	34
DOIs	https://doi.org/10.1039/c9cc01442j
State	Published - 2019

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10.1039/c9cc01442j

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@article{27ad335ae6ec4f49a2bebf3367f18647,

title = "Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery",

abstract = "We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.",

author = "Keonwook Nam and Taehyung Kim and Kim, \{Young Min\} and Kyungjik Yang and Deokyoung Choe and Mensah, \{Lawrence B.\} and Choi, \{Ki Young\} and Roh, \{Young Hoon\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2019.",

year = "2019",

doi = "10.1039/c9cc01442j",

language = "English",

volume = "55",

pages = "4905--4908",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

AU - Nam, Keonwook

AU - Kim, Taehyung

AU - Kim, Young Min

AU - Yang, Kyungjik

AU - Choe, Deokyoung

AU - Mensah, Lawrence B.

AU - Choi, Ki Young

AU - Roh, Young Hoon

PY - 2019

Y1 - 2019

N2 - We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

AB - We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

UR - https://www.scopus.com/pages/publications/85065112772

U2 - 10.1039/c9cc01442j

DO - 10.1039/c9cc01442j

M3 - Article

C2 - 30901006

AN - SCOPUS:85065112772

SN - 1359-7345

VL - 55

SP - 4905

EP - 4908

JO - Chemical Communications

JF - Chemical Communications

IS - 34

ER -

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Abstract

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