Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases

Changjong Moon; Meejung Ahn; Youngheun Jee; Seungdam Heo; Seungjoon Kim; Hyungmin Kim; Ki Bum Sim; Chang Sung Koh; Young Gyun Shin; Taekyun Shin

doi:10.1016/j.neulet.2003.11.038

Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases

Changjong Moon, Meejung Ahn, Youngheun Jee, Seungdam Heo, Seungjoon Kim, Hyungmin Kim, Ki Bum Sim, Chang Sung Koh, Young Gyun Shin, Taekyun Shin

Department of Veterinary Medicine

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17 Scopus citations

Abstract

We studied the effects of oral administration of sodium salicylate on the expression of the pro-inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1 and 2, in rats with experimental autoimmune encephalomyelitis (EAE). Sodium salicylate (200 mg/kg) was administered orally for 13 days after the induction of EAE by immunization with guinea pig myelin basic protein and complete Freund's adjuvant. The onset (P<0.0001) and severity (P<0.05) of EAE paralysis in salicylate-treated animals were delayed and suppressed significantly compared with vehicle-treated controls. Western blot analysis showed that expression of COX-2 and iNOS, but not COX-1, decreased significantly in the spinal cords of salicylate-treated rats compared with vehicle-treated controls (P<0.05) and this finding was paralleled by immunohistochemical observations. These results suggest that the amelioration by salicylate of paralysis in rats with EAE is mediated in part by the suppression of COX and iNOS.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Neuroscience Letters
Volume	356
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2003.11.038
State	Published - 12 Feb 2004

Keywords

Cyclooxygenase
Encephalomyelitis
Nitric oxide synthase
Sodium salicylate

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10.1016/j.neulet.2003.11.038

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Moon, C., Ahn, M., Jee, Y., Heo, S., Kim, S., Kim, H., Sim, K. B., Koh, C. S., Shin, Y. G., & Shin, T. (2004). Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases. Neuroscience Letters, 356(2), 123-126. https://doi.org/10.1016/j.neulet.2003.11.038

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title = "Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases",

abstract = "We studied the effects of oral administration of sodium salicylate on the expression of the pro-inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1 and 2, in rats with experimental autoimmune encephalomyelitis (EAE). Sodium salicylate (200 mg/kg) was administered orally for 13 days after the induction of EAE by immunization with guinea pig myelin basic protein and complete Freund's adjuvant. The onset (P<0.0001) and severity (P<0.05) of EAE paralysis in salicylate-treated animals were delayed and suppressed significantly compared with vehicle-treated controls. Western blot analysis showed that expression of COX-2 and iNOS, but not COX-1, decreased significantly in the spinal cords of salicylate-treated rats compared with vehicle-treated controls (P<0.05) and this finding was paralleled by immunohistochemical observations. These results suggest that the amelioration by salicylate of paralysis in rats with EAE is mediated in part by the suppression of COX and iNOS.",

keywords = "Cyclooxygenase, Encephalomyelitis, Nitric oxide synthase, Sodium salicylate",

author = "Changjong Moon and Meejung Ahn and Youngheun Jee and Seungdam Heo and Seungjoon Kim and Hyungmin Kim and Sim, {Ki Bum} and Koh, {Chang Sung} and Shin, {Young Gyun} and Taekyun Shin",

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day = "12",

doi = "10.1016/j.neulet.2003.11.038",

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Moon, C, Ahn, M, Jee, Y, Heo, S, Kim, S, Kim, H, Sim, KB, Koh, CS, Shin, YG & Shin, T 2004, 'Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases', Neuroscience Letters, vol. 356, no. 2, pp. 123-126. https://doi.org/10.1016/j.neulet.2003.11.038

Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases. / Moon, Changjong; Ahn, Meejung; Jee, Youngheun et al.
In: Neuroscience Letters, Vol. 356, No. 2, 12.02.2004, p. 123-126.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases

AU - Moon, Changjong

AU - Ahn, Meejung

AU - Jee, Youngheun

AU - Heo, Seungdam

AU - Kim, Seungjoon

AU - Kim, Hyungmin

AU - Sim, Ki Bum

AU - Koh, Chang Sung

AU - Shin, Young Gyun

AU - Shin, Taekyun

PY - 2004/2/12

Y1 - 2004/2/12

N2 - We studied the effects of oral administration of sodium salicylate on the expression of the pro-inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1 and 2, in rats with experimental autoimmune encephalomyelitis (EAE). Sodium salicylate (200 mg/kg) was administered orally for 13 days after the induction of EAE by immunization with guinea pig myelin basic protein and complete Freund's adjuvant. The onset (P<0.0001) and severity (P<0.05) of EAE paralysis in salicylate-treated animals were delayed and suppressed significantly compared with vehicle-treated controls. Western blot analysis showed that expression of COX-2 and iNOS, but not COX-1, decreased significantly in the spinal cords of salicylate-treated rats compared with vehicle-treated controls (P<0.05) and this finding was paralleled by immunohistochemical observations. These results suggest that the amelioration by salicylate of paralysis in rats with EAE is mediated in part by the suppression of COX and iNOS.

AB - We studied the effects of oral administration of sodium salicylate on the expression of the pro-inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1 and 2, in rats with experimental autoimmune encephalomyelitis (EAE). Sodium salicylate (200 mg/kg) was administered orally for 13 days after the induction of EAE by immunization with guinea pig myelin basic protein and complete Freund's adjuvant. The onset (P<0.0001) and severity (P<0.05) of EAE paralysis in salicylate-treated animals were delayed and suppressed significantly compared with vehicle-treated controls. Western blot analysis showed that expression of COX-2 and iNOS, but not COX-1, decreased significantly in the spinal cords of salicylate-treated rats compared with vehicle-treated controls (P<0.05) and this finding was paralleled by immunohistochemical observations. These results suggest that the amelioration by salicylate of paralysis in rats with EAE is mediated in part by the suppression of COX and iNOS.

KW - Cyclooxygenase

KW - Encephalomyelitis

KW - Nitric oxide synthase

KW - Sodium salicylate

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AN - SCOPUS:9144253117

SN - 0304-3940

VL - 356

SP - 123

EP - 126

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases

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