Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells

Won Kee Yoon; Ho Jun Kim; Hwa Young Son; Kyu Shik Jeong; Sang Joon Park; Tae Hwan Kim; Sung Ho Kim; Se Ra Kim; Si Yun Ryu

Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells

Won Kee Yoon, Ho Jun Kim, Hwa Young Son, Kyu Shik Jeong, Sang Joon Park, Tae Hwan Kim, Sung Ho Kim, Se Ra Kim, Si Yun Ryu

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression.

Original language	English
Pages (from-to)	2331-2335
Number of pages	5
Journal	Anticancer Research
Volume	24
Issue number	4
State	Published - Jul 2004

Keywords

LFA-1
Neuraminidase
Somatostatin
Substance P

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells",

abstract = "This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression.",

keywords = "LFA-1, Neuraminidase, Somatostatin, Substance P",

author = "Yoon, {Won Kee} and Kim, {Ho Jun} and Son, {Hwa Young} and Jeong, {Kyu Shik} and Park, {Sang Joon} and Kim, {Tae Hwan} and Kim, {Sung Ho} and Kim, {Se Ra} and Ryu, {Si Yun}",

year = "2004",

month = jul,

language = "English",

volume = "24",

pages = "2331--2335",

journal = "Anticancer Research",

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publisher = "International Institute of Anticancer Research",

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T1 - Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells

AU - Yoon, Won Kee

AU - Kim, Ho Jun

AU - Son, Hwa Young

AU - Jeong, Kyu Shik

AU - Park, Sang Joon

AU - Kim, Tae Hwan

AU - Kim, Sung Ho

AU - Kim, Se Ra

AU - Ryu, Si Yun

PY - 2004/7

Y1 - 2004/7

N2 - This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression.

AB - This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression.

KW - LFA-1

KW - Neuraminidase

KW - Somatostatin

KW - Substance P

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AN - SCOPUS:4444247027

SN - 0250-7005

VL - 24

SP - 2331

EP - 2335

JO - Anticancer Research

JF - Anticancer Research

IS - 4

ER -

Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells

Abstract

Keywords

UN SDGs

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