Spatial learning and motor deficits in vacuolar protein sorting-associated protein 13b (Vps13b) mutant mouse

Min Jung Kim, Ro Un Lee, Jihae Oh, Ja Eun Choi, Hyopil Kim, Kyungmin Lee, Su Kyeong Hwang, Jae Hyung Lee, Jin A. Lee, Bong Kiun Kaang, Chae Seok Lim, Yong Seok Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Vacuolar protein sorting-associated protein 13B (VPS13B), also known as COH1, is one of the VPS13 family members which is involved in transmembrane transport, Golgi integrity, and neuritogenesis. Mutations in the VPS13B gene are associated with Cohen syndrome and other cognitive disorders such as intellectual disabilities and autism spectrum disorder (ASD). However, the pathophysiology of VPS13B-associated cognitive deficits is unclear, in part, due to the lack of animal models. Here, we generated a Vps13b exon 2 deletion mutant mouse and analyzed the behavioral phenotypes. We found that Vps13b mutant mice showed reduced activity in open field test and significantly shorter latency to fall in the rotarod test, suggesting that the mutants have motor deficits. In addition, we found that Vps13b mutant mice showed deficits in spatial learning in the hidden platform version of the Morris water maze. The Vps13b mutant mice were normal in other behaviors such as anxiety-like behaviors, working memory and social behaviors. Our results suggest that Vps13b mutant mice may recapitulate key clinical symptoms in Cohen syndrome such as intellectual disability and hypotonia. Vps13b mutant mice may serve as a useful model to investigate the pathophysiology of VPS13B-associated disorders.

Original languageEnglish
Pages (from-to)485-494
Number of pages10
JournalExperimental Neurobiology
Volume28
Issue number4
DOIs
StatePublished - 2019

Keywords

  • Cohen syndrome
  • Learning disability
  • Vps13b

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