Spatiotemporal Evolution of the Primary Glioblastoma Genome

Jinkuk Kim, In Hee Lee, Hee Jin Cho, Chul Kee Park, Yang Soon Jung, Yanghee Kim, So Hee Nam, Byung Sup Kim, Mark D. Johnson, Doo Sik Kong, Ho Jun Seol, Jung Il Lee, Kyeung Min Joo, Yeup Yoon, Woong Yang Park, Jeongwu Lee, Peter J. Park, Do Hyun Nam

Research output: Contribution to journalArticlepeer-review

239 Scopus citations

Abstract

Tumor recurrence following treatment is the major cause of mortality for glioblastoma multiforme (GBM) patients. Thus, insights on the evolutionary process at recurrence are critical for improved patient care. Here, we describe our genomic analyses of the initial and recurrent tumor specimens from each of 38 GBM patients. A substantial divergence in the landscape of driver alterations was associated with distant appearance of a recurrent tumor from the initial tumor, suggesting that the genomic profile of the initial tumor can mislead targeted therapies for the distally recurred tumor. In addition, in contrast to IDH1-mutated gliomas, IDH1-wild-type primary GBMs rarely developed hypermutation following temozolomide (TMZ) treatment, indicating low risk for TMZ-induced hypermutation for these tumors under the standard regimen.

Original languageEnglish
Pages (from-to)318-328
Number of pages11
JournalCancer Cell
Volume28
Issue number3
DOIs
StatePublished - 14 Sep 2015

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