TY - JOUR
T1 - Sprayable Adhesive Nanotherapeutics
T2 - Mussel-Protein-Based Nanoparticles for Highly Efficient Locoregional Cancer Therapy
AU - Jeong, Yeonsu
AU - Jo, Yun Kee
AU - Kim, Bum Jin
AU - Yang, Byeongseon
AU - Joo, Kye Il
AU - Cha, Hyung Joon
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/9/25
Y1 - 2018/9/25
N2 - Following surgical resection for primary treatment of solid tumors, systemic chemotherapy is commonly used to eliminate residual cancer cells to prevent tumor recurrence. However, its clinical outcome is often limited due to insufficient local accumulation and the systemic toxicity of anticancer drugs. Here, we propose a sprayable adhesive nanoparticle (NP)-based drug delivery system using a bioengineered mussel adhesive protein (MAP) for effective locoregional cancer therapy. The MAP NPs could be administered to target surfaces in a surface-independent manner through a simple and easy spray process by virtue of their unique adhesion ability and sufficient dispersion property. Doxorubicin (DOX)-loaded MAP NPs (MAP@DOX NPs) exhibited efficient cellular uptake, endolysosomal trafficking, and subsequent low pH microenvironment-induced DOX release in cancer cells. The locally sprayed MAP@DOX NPs showed a significant inhibition of tumor growth in vivo, resulting from the prolonged retention of the MAP@DOX NPs on the tumor surface. Thus, this adhesive MAP NP-based spray therapeutic system provides a promising approach for topical drug delivery in adjuvant cancer therapy.
AB - Following surgical resection for primary treatment of solid tumors, systemic chemotherapy is commonly used to eliminate residual cancer cells to prevent tumor recurrence. However, its clinical outcome is often limited due to insufficient local accumulation and the systemic toxicity of anticancer drugs. Here, we propose a sprayable adhesive nanoparticle (NP)-based drug delivery system using a bioengineered mussel adhesive protein (MAP) for effective locoregional cancer therapy. The MAP NPs could be administered to target surfaces in a surface-independent manner through a simple and easy spray process by virtue of their unique adhesion ability and sufficient dispersion property. Doxorubicin (DOX)-loaded MAP NPs (MAP@DOX NPs) exhibited efficient cellular uptake, endolysosomal trafficking, and subsequent low pH microenvironment-induced DOX release in cancer cells. The locally sprayed MAP@DOX NPs showed a significant inhibition of tumor growth in vivo, resulting from the prolonged retention of the MAP@DOX NPs on the tumor surface. Thus, this adhesive MAP NP-based spray therapeutic system provides a promising approach for topical drug delivery in adjuvant cancer therapy.
KW - adhesive nanoparticles
KW - adjuvant cancer therapy
KW - locoregional drug delivery
KW - mussel adhesive proteins
KW - surgical spray
UR - http://www.scopus.com/inward/record.url?scp=85050881273&partnerID=8YFLogxK
U2 - 10.1021/acsnano.8b04533
DO - 10.1021/acsnano.8b04533
M3 - Article
C2 - 30052423
AN - SCOPUS:85050881273
SN - 1936-0851
VL - 12
SP - 8909
EP - 8919
JO - ACS Nano
JF - ACS Nano
IS - 9
ER -