Abstract
The dihydroxylation reaction of allylic amines is a facile and useful synthetic method to obtain amino diol structures that are widely found in lots of biologically important natural products. This review will focus on the recent methods of both substrate-controlled and ligand-controlled dihydroxylation reactions of acyclic allylic amines. In addition, several applications of the diastereoselective dihydroxylation methods to asymmetric syntheses of natural products are presented.
Original language | English |
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Pages (from-to) | 437-446 |
Number of pages | 10 |
Journal | Applied Chemistry for Engineering |
Volume | 25 |
Issue number | 5 |
DOIs | |
State | Published - 1 Oct 2014 |
Keywords
- Acyclic conformation
- Asymmetric synthesis
- Dihydroxylation
- Natural product
- Osmium tetroxide