TY - JOUR
T1 - Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists
AU - Shin, Kyoungjin
AU - Chin, Jungwook
AU - Hahn, Dongyup
AU - Lee, Jaehwan
AU - Hwang, Hoosang
AU - Won, Dong Hwan
AU - Ham, Jungyeob
AU - Choi, Hyukjae
AU - Kang, Eunsoo
AU - Kim, Hiyoung
AU - Ju, Moon Kyeong
AU - Nam, Sang Jip
AU - Kang, Heonjoong
PY - 2012/4
Y1 - 2012/4
N2 - Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC 50's 14 and 15 μM.
AB - Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC 50's 14 and 15 μM.
KW - Cholestasis
KW - Dendronephthya gigantea
KW - Farnesoid X-activated receptor
UR - http://www.scopus.com/inward/record.url?scp=84862790074&partnerID=8YFLogxK
U2 - 10.1016/j.steroids.2011.12.027
DO - 10.1016/j.steroids.2011.12.027
M3 - Article
C2 - 22266736
AN - SCOPUS:84862790074
SN - 0039-128X
VL - 77
SP - 355
EP - 359
JO - Steroids
JF - Steroids
IS - 5
ER -